eF-site ID 2xkk-ACEF PDB Code 2xkk Chain A, C, E, F click to enlarge Title CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, and A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE) Classification ISOMERASE/DNA/ANTIBIOTIC Compound TOPOISOMERASE IV Source Acinetobacter baumannii (strain SDF) (2XKK) Sequence A:  ALPGKLTREESELFIVEGDSAGGSAKQARDKNFQAIMPIR GKILNTWEVSSDEVLASQEVHDIAIAIGVDPGSDDLSELR YGKICILADADSDGLHIATLLCALFVKHFPALVEEGHLYV AMPPLFRIDIGKDVHYALDDEELETILKNVKNPQITRFKG LGEMNAIQLRETTMDPNTRRLVQLDLDDAHLTAGLLDKLL AKKRAADRKQWLEQKENRSVAEFTEQAYLNYAMYVIMDRA LPHISDGLKPVQRRIVYAMSELGLKSSGKPKKSARTVGDV LGKYHPHGDSACYEAMVLMAQPFSYRYPLIEGQGNWGSPD DPKSFAAMRXTEAKLSAYSELLLSELGQGTSEWQDNFDGS LKEPITLPARVPNILLNGTTGIAVGMATDIPPHNLREVVK GTIALIRNPQTSDEKLAEYIPAPDLPTKAEIITPPEELLK IQTTGRGSYRMRAVYTIEKNEIVITELPYQVSGSKVITQI ADQMQAKKLPLVVDVRDESDHENPTRLVIVLRSNRIDAEA VMSHLFATTDLESSYRVNLNMIGEDGRPQVKSIRRILLEW IEIRKKTVTRRLQYHLNRIEKRLHILAGLLIAYLDIDTVI RIIREEDQPKPVLMEHFNIDEIQAEAILELKLRHLAKLEE MEIRHEQDELSAKAAIIREQLENPESLKNLIISELKEDAK KFGDERRSPIVA C:  ERKKIVSGPALPGKLADCVGQTREESELFIVEGDSAGGSA KQARDKNFQAIMPIRGKILNTWEVSSDEVLASQEVHDIAI AIGVDPGSDDLSELRYGKICILADADSDGLHIATLLCALF VKHFPALVEEGHLYVAMPPLFRIDIGKDVHYALDDEELET ILKNVKNPQITRFKGLGEMNAIQLRETTMDPNTRRLVQLD LDDAHLTAGLLDKLLAKKRAADRKQWLEQKGATENRSVAE FTEQAYLNYAMYVIMDRALPHISDGLKPVQRRIVYAMSEL GLKSSGKPKKSARTVGDVLGKYHPHGDSACYEAMVLMAQP FSYRYPLIEGQGNWGSPDDPKSFAAMRXTEAKLSAYSELL LSELGQGTSEWQDNFDGSLKEPITLPARVPNILLNGTTGI AVGMATDIPPHNLREVVKGTIALIRNPQTSDEKLAEYIPA PDLPTKAEIITPPEELLKIQTTGRGSYRMRAVYTIEKNEI VITELPYQVSGSKVITQIADQMQAKKLPLVVDVRDESDHE NPTRLVIVLRSNRIDAEAVMSHLFATTDLESSYRVNLNMI GEDGRPQVKSIRRILLEWIEIRKKTVTRRLQYHLNRIEKR LHILAGLLIAYLDIDTVIRIIREEDQPKPVLMEHFNIDEI QAEAILELKLRHLAKLEEMEIRHEQDELSAKAAIIREQLE NPESLKNLIISELKEDAKKFGDERRSPIVAR E:  GGTCATGAATGACTATGCACGTAAAA F:  TTTACGTGCATAGTCATTCATGACCT Description Functional site 1) chain A residue 467 type sequence D description BINDING SITE FOR RESIDUE MG A 2487 source : AC2 2) chain A residue 469 type sequence D description BINDING SITE FOR RESIDUE MG A 2487 source : AC2 3) chain C residue 467 type sequence D description BINDING SITE FOR RESIDUE MG C 2488 source : AC4 4) chain C residue 469 type sequence D description BINDING SITE FOR RESIDUE MG C 2488 source : AC4 5) chain A residue 1124 type sequence X description BINDING SITE FOR RESIDUE MFX E 1100 source : AC5 6) chain E residue 19 type sequence T description BINDING SITE FOR RESIDUE MFX E 1100 source : AC5 7) chain E residue 20 type sequence A description BINDING SITE FOR RESIDUE MFX E 1100 source : AC5 8) chain F residue 15 type sequence T description BINDING SITE FOR RESIDUE MFX E 1100 source : AC5 9) chain F residue 16 type sequence A description BINDING SITE FOR RESIDUE MFX E 1100 source : AC5 10) chain A residue 393-401 type prosite sequence IVEGDSAGG description TOPOISOMERASE_II DNA topoisomerase II signature. IVEGDSAGG source prosite : PS00177

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