eF-site ID 2xk5-AB PDB Code 2xk5 Chain A, B click to enlarge Title Crystal structure of K6-linked diubiquitin Classification PROTEIN BINDING Compound UBIQUITIN Source (UBIQ_HUMAN) Sequence A:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRL B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPQQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRG Description Functional site 1) chain A residue 1 type sequence M description BINDING SITE FOR RESIDUE ZN A 1074 source : AC1 2) chain A residue 16 type sequence E description BINDING SITE FOR RESIDUE ZN A 1074 source : AC1 3) chain A residue 32 type sequence D description BINDING SITE FOR RESIDUE ZN A 1074 source : AC1 4) chain A residue 18 type sequence E description BINDING SITE FOR RESIDUE ZN A 1075 source : AC2 5) chain A residue 18 type sequence E description BINDING SITE FOR RESIDUE ZN A 1075 source : AC2 6) chain A residue 21 type sequence D description BINDING SITE FOR RESIDUE ZN A 1075 source : AC2 7) chain B residue 18 type sequence E description BINDING SITE FOR RESIDUE ZN B 1076 source : AC3 8) chain B residue 18 type sequence E description BINDING SITE FOR RESIDUE ZN B 1076 source : AC3 9) chain B residue 21 type sequence D description BINDING SITE FOR RESIDUE ZN B 1076 source : AC3 10) chain B residue 29 type sequence K description BINDING SITE FOR RESIDUE ZN B 1076 source : AC3 11) chain A residue 64 type sequence E description BINDING SITE FOR RESIDUE ZN A 1076 source : AC4 12) chain A residue 68 type sequence H description BINDING SITE FOR RESIDUE ZN A 1076 source : AC4 13) chain B residue 1 type sequence M description BINDING SITE FOR RESIDUE ZN B 1077 source : AC5 14) chain B residue 16 type sequence E description BINDING SITE FOR RESIDUE ZN B 1077 source : AC5 15) chain B residue 32 type sequence D description BINDING SITE FOR RESIDUE ZN B 1077 source : AC5 16) chain A residue 27 type sequence K description BINDING SITE FOR RESIDUE ZN A 1077 source : AC6 17) chain A residue 52 type sequence D description BINDING SITE FOR RESIDUE ZN A 1077 source : AC6 18) chain B residue 58 type sequence D description BINDING SITE FOR RESIDUE ZN B 1078 source : AC7 19) chain B residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 20) chain B residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 21) chain B residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 22) chain B residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 24) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 25) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 26) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 27) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 28) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9 29) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 30) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 31) chain A residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 32) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPQQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299

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