eF-site ID 2xiq-B PDB Code 2xiq Chain B click to enlarge Title Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin and malonyl-CoA Classification ISOMERASE Compound METHYLMALONYL-COA MUTASE, MITOCHONDRIAL Source (MUTA_HUMAN) Sequence B:  QQPLHPEWAALAKKQLKGKNPEDLIWHTPEGISIKPLYSK RDTMDLPEELPGVKPFTRGPYPTMYTFRPWTIRQYAGFST VEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRG DVGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPV LANFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPP EPSMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAIL ELAYTLADGLEYSRTGLQAGLTIDEFAPRLSFFWGIGMNF YMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSG WSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALG LPTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMECLT NDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARR QARIDSGSEVIVGVNKYQLEKEDTVEVLAIDNTSVRNRQI EKLKKIKSSRDQALAERCLAALTECAASGDGNILALAVDA SRARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESK EITSAIKRVHKFMEREGRRPRLLVAKMGQDGHDRGAKVIA TGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGVSTLA AGHKTLVPELIKELNSLGRPDILVMCGGVIPPQDYEFLFE VGVSNVFGPGTRIPKAAVQVLDDIEKCLEKKQQ Description Functional site 1) chain B residue 50 type sequence Q description BINDING SITE FOR RESIDUE MLC A 5001 source : AC3 2) chain B residue 110 type sequence Y description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 3) chain B residue 138 type sequence F description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 4) chain B residue 140 type sequence L description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 5) chain B residue 143 type sequence H description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 6) chain B residue 160 type sequence A description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 7) chain B residue 227 type sequence V description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 8) chain B residue 228 type sequence R description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 9) chain B residue 230 type sequence T description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 10) chain B residue 264 type sequence Y description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 11) chain B residue 268 type sequence E description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 12) chain B residue 355 type sequence G description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 13) chain B residue 356 type sequence W description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 14) chain B residue 358 type sequence L description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 15) chain B residue 392 type sequence E description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 16) chain B residue 395 type sequence G description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 17) chain B residue 396 type sequence L description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 18) chain B residue 476 type sequence Q description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 19) chain B residue 626 type sequence G description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 20) chain B residue 627 type sequence H description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 21) chain B residue 628 type sequence D description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 22) chain B residue 629 type sequence R description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 23) chain B residue 630 type sequence G description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 24) chain B residue 634 type sequence I description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 25) chain B residue 670 type sequence G description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 26) chain B residue 672 type sequence S description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 27) chain B residue 674 type sequence L description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 28) chain B residue 676 type sequence A description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 29) chain B residue 702 type sequence G description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 30) chain B residue 703 type sequence G description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 31) chain B residue 704 type sequence V description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 32) chain B residue 722 type sequence F description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 33) chain B residue 723 type sequence G description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 34) chain B residue 726 type sequence T description BINDING SITE FOR RESIDUE B12 B 3001 source : AC4 35) chain B residue 110 type sequence Y description BINDING SITE FOR RESIDUE 5AD B 4001 source : AC5 36) chain B residue 112 type sequence G description BINDING SITE FOR RESIDUE 5AD B 4001 source : AC5 37) chain B residue 137 type sequence A description BINDING SITE FOR RESIDUE 5AD B 4001 source : AC5 38) chain B residue 160 type sequence A description BINDING SITE FOR RESIDUE 5AD B 4001 source : AC5 39) chain B residue 264 type sequence Y description BINDING SITE FOR RESIDUE 5AD B 4001 source : AC5 40) chain B residue 352 type sequence Q description BINDING SITE FOR RESIDUE 5AD B 4001 source : AC5 41) chain B residue 388 type sequence N description BINDING SITE FOR RESIDUE 5AD B 4001 source : AC5 42) chain B residue 392 type sequence E description BINDING SITE FOR RESIDUE 5AD B 4001 source : AC5 43) chain B residue 396 type sequence L description BINDING SITE FOR RESIDUE 5AD B 4001 source : AC5 44) chain B residue 397 type sequence P description BINDING SITE FOR RESIDUE 5AD B 4001 source : AC5 45) chain B residue 96 type sequence Y description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 46) chain B residue 98 type sequence T description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 47) chain B residue 99 type sequence M description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 48) chain B residue 102 type sequence F description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 49) chain B residue 103 type sequence R description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 50) chain B residue 106 type sequence T description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 51) chain B residue 108 type sequence R description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 52) chain B residue 110 type sequence Y description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 53) chain B residue 185 type sequence S description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 54) chain B residue 187 type sequence T description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 55) chain B residue 216 type sequence T description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 56) chain B residue 218 type sequence Q description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 57) chain B residue 228 type sequence R description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 58) chain B residue 255 type sequence K description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 59) chain B residue 257 type sequence N description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 60) chain B residue 265 type sequence H description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 61) chain B residue 304 type sequence R description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 62) chain B residue 306 type sequence S description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 63) chain B residue 308 type sequence F description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 64) chain B residue 348 type sequence R description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 65) chain B residue 349 type sequence A description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 66) chain B residue 350 type sequence H description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 67) chain B residue 352 type sequence Q description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 68) chain B residue 383 type sequence Q description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 69) chain B residue 384 type sequence S description BINDING SITE FOR RESIDUE MLC B 5001 source : AC6 70) chain B residue 627 type BINDING sequence H description axial binding residue => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI2 71) chain B residue 89 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P16332 source Swiss-Prot : SWS_FT_FI3 72) chain B residue 212 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P16332 source Swiss-Prot : SWS_FT_FI3 73) chain B residue 335 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P16332 source Swiss-Prot : SWS_FT_FI3 74) chain B residue 602 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P16332 source Swiss-Prot : SWS_FT_FI3 75) chain B residue 343 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P16332 source Swiss-Prot : SWS_FT_FI4 76) chain B residue 595 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P16332 source Swiss-Prot : SWS_FT_FI4 77) chain B residue 481 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5 78) chain B residue 96 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 79) chain B residue 106 type BINDING sequence T description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 80) chain B residue 216 type BINDING sequence T description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 81) chain B residue 228 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 82) chain B residue 255 type BINDING sequence K description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 83) chain B residue 265 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 84) chain B residue 304 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 85) chain B residue 50 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1

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