eF-site ID 2xij-A PDB Code 2xij Chain A click to enlarge Title Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin Classification ISOMERASE Compound METHYLMALONYL-COA MUTASE, MITOCHONDRIAL Source Homo sapiens (Human) (MUTA_HUMAN) Sequence A:  QQPLHPEWAALAKKQLKGKNPEDLIWHTPEGISIKPLYSK RDTMDLPEELPGVKPFTRGPYPTMYTFRPWTIRQYAGFST VEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRG DVGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPV LANFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPP EPSMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAIL ELAYTLADGLEYSRTGLQAGLTIDEFAPRLSFFWGIGMNF YMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSG WSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALG LPTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMECLT NDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARR QARIDSGSEVIVGVNKYQLEKEDTVEVLAIDNTSVRNRQI EKLKKIKSSRDQALAERCLAALTECAASGDGNILALAVDA SRARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESK EITSAIKRVHKFMEREGRRPRLLVAKMGQDGHDRGAKVIA TGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGVSTLA AGHKTLVPELIKELNSLGRPDILVMCGGVIPPQDYEFLFE VGVSNVFGPGTRIPKAAVQVLDDIEKCLEK Description Functional site 1) chain A residue 138 type sequence F description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 2) chain A residue 140 type sequence L description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 3) chain A residue 143 type sequence H description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 4) chain A residue 160 type sequence A description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 5) chain A residue 227 type sequence V description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 6) chain A residue 228 type sequence R description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 7) chain A residue 230 type sequence T description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 8) chain A residue 268 type sequence E description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 9) chain A residue 356 type sequence W description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 10) chain A residue 392 type sequence E description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 11) chain A residue 393 type sequence A description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 12) chain A residue 394 type sequence L description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 13) chain A residue 395 type sequence G description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 14) chain A residue 476 type sequence Q description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 15) chain A residue 626 type sequence G description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 16) chain A residue 627 type sequence H description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 17) chain A residue 628 type sequence D description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 18) chain A residue 629 type sequence R description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 19) chain A residue 630 type sequence G description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 20) chain A residue 634 type sequence I description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 21) chain A residue 670 type sequence G description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 22) chain A residue 672 type sequence S description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 23) chain A residue 674 type sequence L description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 24) chain A residue 675 type sequence A description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 25) chain A residue 676 type sequence A description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 26) chain A residue 702 type sequence G description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 27) chain A residue 703 type sequence G description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 28) chain A residue 704 type sequence V description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 29) chain A residue 722 type sequence F description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 30) chain A residue 723 type sequence G description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 31) chain A residue 724 type sequence P description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 32) chain A residue 726 type sequence T description BINDING SITE FOR RESIDUE B12 A 800 source : AC1 33) chain A residue 160 type sequence A description BINDING SITE FOR RESIDUE 5AD A 1746 source : AC2 34) chain A residue 352 type sequence Q description BINDING SITE FOR RESIDUE 5AD A 1746 source : AC2 35) chain A residue 396 type sequence L description BINDING SITE FOR RESIDUE 5AD A 1746 source : AC2 36) chain A residue 613 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1747 source : AC3 37) chain A residue 613 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1747 source : AC3 38) chain A residue 614 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1747 source : AC3 39) chain A residue 614 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1747 source : AC3 40) chain A residue 616 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1747 source : AC3 41) chain A residue 616 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1747 source : AC3 42) chain A residue 146 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1748 source : AC4 43) chain A residue 150 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1748 source : AC4 44) chain A residue 152 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1748 source : AC4 45) chain A residue 594 type sequence S description BINDING SITE FOR RESIDUE EDO A 1749 source : AC5 46) chain A residue 595 type sequence K description BINDING SITE FOR RESIDUE EDO A 1749 source : AC5 47) chain A residue 596 type sequence E description BINDING SITE FOR RESIDUE EDO A 1749 source : AC5 48) chain A residue 65 type sequence E description BINDING SITE FOR RESIDUE EDO A 1750 source : AC6 49) chain A residue 272 type sequence D description BINDING SITE FOR RESIDUE EDO A 1750 source : AC6 50) chain A residue 274 type sequence I description BINDING SITE FOR RESIDUE EDO A 1750 source : AC6 51) chain A residue 58 type sequence D description BINDING SITE FOR RESIDUE EDO A 1751 source : AC7 52) chain A residue 60 type sequence I description BINDING SITE FOR RESIDUE EDO A 1751 source : AC7 53) chain A residue 61 type sequence W description BINDING SITE FOR RESIDUE EDO A 1751 source : AC7 54) chain A residue 420 type sequence K description BINDING SITE FOR RESIDUE EDO A 1751 source : AC7 55) chain A residue 108 type sequence R description BINDING SITE FOR RESIDUE EDO A 1752 source : AC8 56) chain A residue 306 type sequence S description BINDING SITE FOR RESIDUE EDO A 1752 source : AC8 57) chain A residue 350 type sequence H description BINDING SITE FOR RESIDUE EDO A 1752 source : AC8 58) chain A residue 384 type sequence S description BINDING SITE FOR RESIDUE EDO A 1752 source : AC8 59) chain A residue 249 type sequence T description BINDING SITE FOR RESIDUE EDO A 1757 source : AC9 60) chain A residue 250 type sequence A description BINDING SITE FOR RESIDUE EDO A 1757 source : AC9 61) chain A residue 258 type sequence S description BINDING SITE FOR RESIDUE EDO A 1757 source : AC9 62) chain A residue 304 type sequence R description BINDING SITE FOR RESIDUE EDO A 1757 source : AC9 63) chain A residue 117 type sequence E description BINDING SITE FOR RESIDUE EDO A 1753 source : BC1 64) chain A residue 510 type sequence V description BINDING SITE FOR RESIDUE EDO A 1753 source : BC1 65) chain A residue 514 type sequence Q description BINDING SITE FOR RESIDUE EDO A 1753 source : BC1 66) chain A residue 517 type sequence K description BINDING SITE FOR RESIDUE EDO A 1753 source : BC1 67) chain A residue 110 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1754 source : BC2 68) chain A residue 185 type sequence S description BINDING SITE FOR RESIDUE EDO A 1754 source : BC2 69) chain A residue 186 type sequence M description BINDING SITE FOR RESIDUE EDO A 1754 source : BC2 70) chain A residue 216 type sequence T description BINDING SITE FOR RESIDUE EDO A 1754 source : BC2 71) chain A residue 218 type sequence Q description BINDING SITE FOR RESIDUE EDO A 1754 source : BC2 72) chain A residue 260 type sequence S description BINDING SITE FOR RESIDUE EDO A 1754 source : BC2 73) chain A residue 308 type sequence F description BINDING SITE FOR RESIDUE EDO A 1754 source : BC2 74) chain A residue 695 type sequence P description BINDING SITE FOR RESIDUE EDO A 1755 source : BC3 75) chain A residue 697 type sequence I description BINDING SITE FOR RESIDUE EDO A 1755 source : BC3 76) chain A residue 107 type sequence I description BINDING SITE FOR RESIDUE BTB A 1756 source : BC4 77) chain A residue 108 type sequence R description BINDING SITE FOR RESIDUE BTB A 1756 source : BC4 78) chain A residue 109 type sequence Q description BINDING SITE FOR RESIDUE BTB A 1756 source : BC4 79) chain A residue 110 type sequence Y description BINDING SITE FOR RESIDUE BTB A 1756 source : BC4 80) chain A residue 111 type sequence A description BINDING SITE FOR RESIDUE BTB A 1756 source : BC4 81) chain A residue 131 type sequence Q description BINDING SITE FOR RESIDUE BTB A 1756 source : BC4 82) chain A residue 135 type sequence S description BINDING SITE FOR RESIDUE BTB A 1756 source : BC4 83) chain A residue 406 type sequence R description BINDING SITE FOR RESIDUE BTB A 1756 source : BC4 84) chain A residue 627 type BINDING sequence H description axial binding residue => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI2 85) chain A residue 89 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P16332 source Swiss-Prot : SWS_FT_FI3 86) chain A residue 212 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P16332 source Swiss-Prot : SWS_FT_FI3 87) chain A residue 335 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P16332 source Swiss-Prot : SWS_FT_FI3 88) chain A residue 602 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P16332 source Swiss-Prot : SWS_FT_FI3 89) chain A residue 343 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P16332 source Swiss-Prot : SWS_FT_FI4 90) chain A residue 595 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P16332 source Swiss-Prot : SWS_FT_FI4 91) chain A residue 50 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 92) chain A residue 96 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 93) chain A residue 106 type BINDING sequence T description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 94) chain A residue 216 type BINDING sequence T description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 95) chain A residue 228 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 96) chain A residue 255 type BINDING sequence K description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 97) chain A residue 265 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 98) chain A residue 304 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20876572 source Swiss-Prot : SWS_FT_FI1 99) chain A residue 481 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5 100) chain A residue 403-428 type prosite sequence RIARNTQIIIQEESGIPKVADPWGGS description METMALONYL_COA_MUTASE Methylmalonyl-CoA mutase signature. RIARNTqiIIqEEsgipKvaDPwGGS source prosite : PS00544

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