eF-site ID 2xfh-A
PDB Code 2xfh
Chain A

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Title Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.
Classification OXIDOREDUCTASE
Compound ERYTHROMYCIN B/D C-12 HYDROXYLASE
Source Saccharopolyspora erythraea (strain NRRL 23338) (CPXQ_SACEN)
Sequence A:  IDEVPGMADETALLDWLGTMREKQPVWQDRYGVWHVFRHA
DVQTVLRDTATFSSDPTRVIEGASPTPGMIHEIDPPEHRA
LRKVVSSAFTPRTISDLEPRIRDVTRSLLADAGESFDLVD
VLAFPLPVTIVAELLGLPPMDHEQFGDWSGALVDIQMDDP
TDPALAERIADVLNPLTAYLKARCAERRADPGDDLISRLV
LAEVDGRALDDEEAANFSTALLLAGHITTTVLLGNIVRTL
DEHPAHWDAAAEDPGRIPAIVEEVLRYRPPFPQMQRTTTK
ATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSRK
SGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARFGRL
TVDRDDERLRHFEQIVLGTRHLPVLAGSSPRQSA
Description


Functional site

1) chain A
residue 87
type
sequence I
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

2) chain A
residue 88
type
sequence H
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

3) chain A
residue 95
type
sequence H
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

4) chain A
residue 99
type
sequence R
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

5) chain A
residue 238
type
sequence L
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

6) chain A
residue 241
type
sequence A
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

7) chain A
residue 245
type
sequence T
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

8) chain A
residue 288
type
sequence F
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

9) chain A
residue 291
type
sequence M
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

10) chain A
residue 293
type
sequence R
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

11) chain A
residue 345
type
sequence S
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

12) chain A
residue 346
type
sequence F
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

13) chain A
residue 347
type
sequence G
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

14) chain A
residue 351
type
sequence H
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

15) chain A
residue 353
type
sequence C
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

16) chain A
residue 355
type
sequence G
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

17) chain A
residue 359
type
sequence A
description BINDING SITE FOR RESIDUE HEM A 1412
source : AC1

18) chain A
residue 88
type
sequence H
description BINDING SITE FOR RESIDUE CL6 A 1413
source : AC2

19) chain A
residue 173
type
sequence Q
description BINDING SITE FOR RESIDUE CL6 A 1413
source : AC2

20) chain A
residue 241
type
sequence A
description BINDING SITE FOR RESIDUE CL6 A 1413
source : AC2

21) chain A
residue 245
type
sequence T
description BINDING SITE FOR RESIDUE CL6 A 1413
source : AC2

22) chain A
residue 288
type
sequence F
description BINDING SITE FOR RESIDUE CL6 A 1413
source : AC2

23) chain A
residue 86
type
sequence M
description BINDING SITE FOR RESIDUE CL6 A 1414
source : AC3

24) chain A
residue 88
type
sequence H
description BINDING SITE FOR RESIDUE CL6 A 1414
source : AC3

25) chain A
residue 169
type
sequence L
description BINDING SITE FOR RESIDUE CL6 A 1414
source : AC3

26) chain A
residue 173
type
sequence Q
description BINDING SITE FOR RESIDUE CL6 A 1414
source : AC3

27) chain A
residue 186
type
sequence I
description BINDING SITE FOR RESIDUE CL6 A 1414
source : AC3

28) chain A
residue 190
type
sequence L
description BINDING SITE FOR RESIDUE CL6 A 1414
source : AC3

29) chain A
residue 240
type
sequence L
description BINDING SITE FOR RESIDUE CL6 A 1414
source : AC3

30) chain A
residue 92
type
sequence P
description BINDING SITE FOR RESIDUE DMS A 1415
source : AC4

31) chain A
residue 95
type
sequence H
description BINDING SITE FOR RESIDUE DMS A 1415
source : AC4

32) chain A
residue 96
type
sequence R
description BINDING SITE FOR RESIDUE DMS A 1415
source : AC4

33) chain A
residue 184
type
sequence E
description BINDING SITE FOR RESIDUE DMS A 1415
source : AC4

34) chain A
residue 350
type
sequence V
description BINDING SITE FOR RESIDUE DMS A 1415
source : AC4

35) chain A
residue 88
type BINDING
sequence H
description
source Swiss-Prot : SWS_FT_FI1

36) chain A
residue 95
type BINDING
sequence H
description
source Swiss-Prot : SWS_FT_FI1

37) chain A
residue 99
type BINDING
sequence R
description
source Swiss-Prot : SWS_FT_FI1

38) chain A
residue 292
type BINDING
sequence Q
description
source Swiss-Prot : SWS_FT_FI1

39) chain A
residue 293
type BINDING
sequence R
description
source Swiss-Prot : SWS_FT_FI1

40) chain A
residue 351
type BINDING
sequence H
description
source Swiss-Prot : SWS_FT_FI1

41) chain A
residue 346-355
type prosite
sequence FGHGVHFCLG
description CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGVHFCLG
source prosite : PS00086

42) chain A
residue 353
type BINDING
sequence C
description axial binding residue
source Swiss-Prot : SWS_FT_FI2


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