eF-site ID 2xf0-A PDB Code 2xf0 Chain A click to enlarge Title Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors Classification TRANSFERASE Compound SERINE/THREONINE-PROTEIN KINASE CHK1 Source Homo sapiens (Human) (CHK1_HUMAN) Sequence A:  PFVEDWDLVQTLGEVQLAVNRVTEEAVAVKIVDNIKKEIC INKMLNHENVVKFYGHRREIQYLFLEYCSGGELFDRIEPD IGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD ERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELL KRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYS DWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDI KKDRWYNKPLK Description Functional site 1) chain A residue 15 type sequence L description BINDING SITE FOR RESIDUE 4UB A 1271 source : AC1 2) chain A residue 23 type sequence V description BINDING SITE FOR RESIDUE 4UB A 1271 source : AC1 3) chain A residue 36 type sequence A description BINDING SITE FOR RESIDUE 4UB A 1271 source : AC1 4) chain A residue 85 type sequence E description BINDING SITE FOR RESIDUE 4UB A 1271 source : AC1 5) chain A residue 86 type sequence Y description BINDING SITE FOR RESIDUE 4UB A 1271 source : AC1 6) chain A residue 87 type sequence C description BINDING SITE FOR RESIDUE 4UB A 1271 source : AC1 7) chain A residue 90 type sequence G description BINDING SITE FOR RESIDUE 4UB A 1271 source : AC1 8) chain A residue 137 type sequence L description BINDING SITE FOR RESIDUE 4UB A 1271 source : AC1 9) chain A residue 147 type sequence S description BINDING SITE FOR RESIDUE 4UB A 1271 source : AC1 10) chain A residue 57 type sequence C description BINDING SITE FOR RESIDUE EDO A 1272 source : AC2 11) chain A residue 61 type sequence M description BINDING SITE FOR RESIDUE EDO A 1272 source : AC2 12) chain A residue 97 type sequence E description BINDING SITE FOR RESIDUE EDO A 1272 source : AC2 13) chain A residue 103 type sequence P description BINDING SITE FOR RESIDUE EDO A 1273 source : AC3 14) chain A residue 157 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1273 source : AC3 15) chain A residue 158 type sequence N description BINDING SITE FOR RESIDUE EDO A 1273 source : AC3 16) chain A residue 123 type sequence G description BINDING SITE FOR RESIDUE EDO A 1274 source : AC4 17) chain A residue 124 type sequence I description BINDING SITE FOR RESIDUE EDO A 1274 source : AC4 18) chain A residue 125 type sequence G description BINDING SITE FOR RESIDUE EDO A 1274 source : AC4 19) chain A residue 156 type sequence R description BINDING SITE FOR RESIDUE EDO A 1274 source : AC4 20) chain A residue 158 type sequence N description BINDING SITE FOR RESIDUE EDO A 1274 source : AC4 21) chain A residue 159 type sequence N description BINDING SITE FOR RESIDUE EDO A 1274 source : AC4 22) chain A residue 221 type sequence W description BINDING SITE FOR RESIDUE EDO A 1275 source : AC5 23) chain A residue 224 type sequence K description BINDING SITE FOR RESIDUE EDO A 1275 source : AC5 24) chain A residue 243 type sequence H description BINDING SITE FOR RESIDUE EDO A 1275 source : AC5 25) chain A residue 246 type sequence L description BINDING SITE FOR RESIDUE EDO A 1275 source : AC5 26) chain A residue 130 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 27) chain A residue 15 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 38 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 15-38 type prosite sequence LGEVQLAVNRVTEEAVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAYGEVQlAvnrvteea..........VAVK source prosite : PS00107 30) chain A residue 126-138 type prosite sequence ITHRDIKPENLLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ItHrDIKpeNLLL source prosite : PS00108 31) chain A residue 132 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:32357935 source Swiss-Prot : SWS_FT_FI5

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