eF-site ID 2xew-L PDB Code 2xew Chain L click to enlarge Title Crystal structure of K11-linked diubiquitin Classification CELL CYCLE Compound UBIQUITIN Source (UBIQ_HUMAN) Sequence L:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR Description Functional site 1) chain L residue 44 type sequence I description BINDING SITE FOR RESIDUE EDO D 1077 source : BC1 2) chain L residue 45 type sequence F description BINDING SITE FOR RESIDUE EDO D 1077 source : BC1 3) chain L residue 46 type sequence A description BINDING SITE FOR RESIDUE EDO D 1077 source : BC1 4) chain L residue 47 type sequence G description BINDING SITE FOR RESIDUE EDO D 1077 source : BC1 5) chain L residue 68 type sequence H description BINDING SITE FOR RESIDUE EDO D 1077 source : BC1 6) chain L residue 7 type sequence T description BINDING SITE FOR RESIDUE EDO L 1075 source : CC3 7) chain L residue 9 type sequence T description BINDING SITE FOR RESIDUE EDO L 1075 source : CC3 8) chain L residue 11 type sequence K description BINDING SITE FOR RESIDUE EDO L 1075 source : CC3 9) chain L residue 70 type sequence V description BINDING SITE FOR RESIDUE EDO L 1076 source : CC4 10) chain L residue 71 type sequence L description BINDING SITE FOR RESIDUE EDO L 1076 source : CC4 11) chain L residue 1 type sequence M description BINDING SITE FOR RESIDUE EDO L 1077 source : CC5 12) chain L residue 2 type sequence Q description BINDING SITE FOR RESIDUE EDO L 1077 source : CC5 13) chain L residue 14 type sequence T description BINDING SITE FOR RESIDUE EDO L 1077 source : CC5 14) chain L residue 15 type sequence L description BINDING SITE FOR RESIDUE EDO L 1077 source : CC5 15) chain L residue 16 type sequence E description BINDING SITE FOR RESIDUE EDO L 1077 source : CC5 16) chain L residue 25 type sequence N description BINDING SITE FOR RESIDUE CL L 1078 source : CC6 17) chain L residue 28 type sequence A description BINDING SITE FOR RESIDUE CL L 1078 source : CC6 18) chain L residue 14 type sequence T description BINDING SITE FOR RESIDUE CL L 1079 source : CC7 19) chain L residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 20) chain L residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 21) chain L residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 22) chain L residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 23) chain L residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 24) chain L residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 25) chain L residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 26) chain L residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 27) chain L residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 28) chain L residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 29) chain L residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 30) chain L residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9

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