eF-site ID 2xew-I PDB Code 2xew Chain I click to enlarge Title Crystal structure of K11-linked diubiquitin Classification CELL CYCLE Compound UBIQUITIN Source (UBIQ_HUMAN) Sequence I:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Description Functional site 1) chain I residue 44 type sequence I description BINDING SITE FOR RESIDUE EDO I 1077 source : BC8 2) chain I residue 45 type sequence F description BINDING SITE FOR RESIDUE EDO I 1077 source : BC8 3) chain I residue 46 type sequence A description BINDING SITE FOR RESIDUE EDO I 1077 source : BC8 4) chain I residue 47 type sequence G description BINDING SITE FOR RESIDUE EDO I 1077 source : BC8 5) chain I residue 68 type sequence H description BINDING SITE FOR RESIDUE EDO I 1077 source : BC8 6) chain I residue 42 type sequence R description BINDING SITE FOR RESIDUE CL I 1078 source : BC9 7) chain I residue 70 type sequence V description BINDING SITE FOR RESIDUE EDO L 1075 source : CC3 8) chain I residue 71 type sequence L description BINDING SITE FOR RESIDUE EDO L 1075 source : CC3 9) chain I residue 7 type sequence T description BINDING SITE FOR RESIDUE EDO L 1076 source : CC4 10) chain I residue 9 type sequence T description BINDING SITE FOR RESIDUE EDO L 1076 source : CC4 11) chain I residue 11 type sequence K description BINDING SITE FOR RESIDUE EDO L 1076 source : CC4 12) chain I residue 16 type sequence E description BINDING SITE FOR RESIDUE CL L 1080 source : CC8 13) chain I residue 33 type sequence K description BINDING SITE FOR RESIDUE CL L 1080 source : CC8 14) chain I residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 15) chain I residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 16) chain I residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 17) chain I residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 18) chain I residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 19) chain I residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 20) chain I residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 21) chain I residue 76 type MOD_RES sequence G description ADP-ribosylglycine => ECO:0000269|PubMed:28525742 source Swiss-Prot : SWS_FT_FI5 22) chain I residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 23) chain I residue 76 type CROSSLNK sequence G description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) source Swiss-Prot : SWS_FT_FI7 24) chain I residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 25) chain I residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 26) chain I residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 27) chain I residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9

Display surface Download Links