eF-site ID 2xew-A PDB Code 2xew Chain A click to enlarge Title Crystal structure of K11-linked diubiquitin Classification CELL CYCLE Compound UBIQUITIN Source (UBIQ_HUMAN) Sequence A:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Description Functional site 1) chain A residue 70 type sequence V description BINDING SITE FOR RESIDUE EDO A 1077 source : AC1 2) chain A residue 71 type sequence L description BINDING SITE FOR RESIDUE EDO A 1077 source : AC1 3) chain A residue 7 type sequence T description BINDING SITE FOR RESIDUE EDO A 1078 source : AC2 4) chain A residue 9 type sequence T description BINDING SITE FOR RESIDUE EDO A 1078 source : AC2 5) chain A residue 11 type sequence K description BINDING SITE FOR RESIDUE EDO A 1078 source : AC2 6) chain A residue 45 type sequence F description BINDING SITE FOR RESIDUE EDO A 1079 source : AC3 7) chain A residue 65 type sequence S description BINDING SITE FOR RESIDUE EDO A 1079 source : AC3 8) chain A residue 66 type sequence T description BINDING SITE FOR RESIDUE EDO A 1079 source : AC3 9) chain A residue 16 type sequence E description BINDING SITE FOR RESIDUE CL A 1080 source : AC4 10) chain A residue 33 type sequence K description BINDING SITE FOR RESIDUE CL A 1080 source : AC4 11) chain A residue 18 type sequence E description BINDING SITE FOR RESIDUE EDO B 1078 source : AC6 12) chain A residue 19 type sequence P description BINDING SITE FOR RESIDUE EDO B 1078 source : AC6 13) chain A residue 20 type sequence S description BINDING SITE FOR RESIDUE EDO B 1078 source : AC6 14) chain A residue 53 type sequence G description BINDING SITE FOR RESIDUE EDO B 1079 source : AC7 15) chain A residue 37 type sequence P description BINDING SITE FOR RESIDUE FLC F 1077 source : BC4 16) chain A residue 39 type sequence D description BINDING SITE FOR RESIDUE FLC F 1077 source : BC4 17) chain A residue 40 type sequence Q description BINDING SITE FOR RESIDUE FLC F 1077 source : BC4 18) chain A residue 74 type sequence R description BINDING SITE FOR RESIDUE FLC F 1077 source : BC4 19) chain A residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 20) chain A residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 21) chain A residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 22) chain A residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 23) chain A residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 24) chain A residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 25) chain A residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 26) chain A residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 28) chain A residue 76 type MOD_RES sequence G description ADP-ribosylglycine => ECO:0000269|PubMed:28525742 source Swiss-Prot : SWS_FT_FI5 29) chain A residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 30) chain A residue 76 type CROSSLNK sequence G description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) source Swiss-Prot : SWS_FT_FI7 31) chain A residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 32) chain A residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 33) chain A residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9

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