eF-site ID 2xew-A
PDB Code 2xew
Chain A

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Title Crystal structure of K11-linked diubiquitin
Classification CELL CYCLE
Compound UBIQUITIN
Source (UBIQ_HUMAN)
Sequence A:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ
QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG
Description


Functional site

1) chain A
residue 70
type
sequence V
description BINDING SITE FOR RESIDUE EDO A 1077
source : AC1

2) chain A
residue 71
type
sequence L
description BINDING SITE FOR RESIDUE EDO A 1077
source : AC1

3) chain A
residue 7
type
sequence T
description BINDING SITE FOR RESIDUE EDO A 1078
source : AC2

4) chain A
residue 9
type
sequence T
description BINDING SITE FOR RESIDUE EDO A 1078
source : AC2

5) chain A
residue 11
type
sequence K
description BINDING SITE FOR RESIDUE EDO A 1078
source : AC2

6) chain A
residue 45
type
sequence F
description BINDING SITE FOR RESIDUE EDO A 1079
source : AC3

7) chain A
residue 65
type
sequence S
description BINDING SITE FOR RESIDUE EDO A 1079
source : AC3

8) chain A
residue 66
type
sequence T
description BINDING SITE FOR RESIDUE EDO A 1079
source : AC3

9) chain A
residue 16
type
sequence E
description BINDING SITE FOR RESIDUE CL A 1080
source : AC4

10) chain A
residue 33
type
sequence K
description BINDING SITE FOR RESIDUE CL A 1080
source : AC4

11) chain A
residue 18
type
sequence E
description BINDING SITE FOR RESIDUE EDO B 1078
source : AC6

12) chain A
residue 19
type
sequence P
description BINDING SITE FOR RESIDUE EDO B 1078
source : AC6

13) chain A
residue 20
type
sequence S
description BINDING SITE FOR RESIDUE EDO B 1078
source : AC6

14) chain A
residue 53
type
sequence G
description BINDING SITE FOR RESIDUE EDO B 1079
source : AC7

15) chain A
residue 37
type
sequence P
description BINDING SITE FOR RESIDUE FLC F 1077
source : BC4

16) chain A
residue 39
type
sequence D
description BINDING SITE FOR RESIDUE FLC F 1077
source : BC4

17) chain A
residue 40
type
sequence Q
description BINDING SITE FOR RESIDUE FLC F 1077
source : BC4

18) chain A
residue 74
type
sequence R
description BINDING SITE FOR RESIDUE FLC F 1077
source : BC4

19) chain A
residue 27-52
type prosite
sequence KAKIQDKEGIPPDQQRLIFAGKQLED
description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD
source prosite : PS00299

20) chain A
residue 54
type SITE
sequence R
description Interacts with activating enzyme
source Swiss-Prot : SWS_FT_FI1

21) chain A
residue 72
type SITE
sequence R
description Interacts with activating enzyme
source Swiss-Prot : SWS_FT_FI1

22) chain A
residue 29
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127
source Swiss-Prot : SWS_FT_FI10

23) chain A
residue 33
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577
source Swiss-Prot : SWS_FT_FI11

24) chain A
residue 63
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106
source Swiss-Prot : SWS_FT_FI12

25) chain A
residue 68
type SITE
sequence H
description Essential for function
source Swiss-Prot : SWS_FT_FI2

26) chain A
residue 65
type MOD_RES
sequence S
description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
source Swiss-Prot : SWS_FT_FI3

27) chain A
residue 66
type MOD_RES
sequence T
description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457
source Swiss-Prot : SWS_FT_FI4

28) chain A
residue 76
type MOD_RES
sequence G
description ADP-ribosylglycine => ECO:0000269|PubMed:28525742
source Swiss-Prot : SWS_FT_FI5

29) chain A
residue 6
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603
source Swiss-Prot : SWS_FT_FI6

30) chain A
residue 76
type CROSSLNK
sequence G
description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
source Swiss-Prot : SWS_FT_FI7

31) chain A
residue 11
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144
source Swiss-Prot : SWS_FT_FI8

32) chain A
residue 48
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144
source Swiss-Prot : SWS_FT_FI8

33) chain A
residue 27
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860
source Swiss-Prot : SWS_FT_FI9


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