eF-site ID 2xcn-ABCD PDB Code 2xcn Chain A, B, C, D click to enlarge Title Crystal structure of HCV NS3 protease with a boronate inhibitor Classification HYDROLASE Compound NS3 PROTEASE Source Hepatitis C virus (C9WU77_9HEPC) Sequence A:  APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAT QTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQ DLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRG DSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCT RGVAKAVDFIPVENLETTMR B:  QVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASP KGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLV TRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPA GHAVGLFRAAVCTRGVAKAVDFIPVENLETTMR C:  KGSVVIVGRIVLSGKPAIIPK D:  GSVVIVGRIVLSGKPA Description (1)  NS3 PROTEASE, NS4A Functional site 1) chain A residue 57 type sequence H description BINDING SITE FOR RESIDUE C8D A 1181 source : AC1 2) chain A residue 123 type sequence R description BINDING SITE FOR RESIDUE C8D A 1181 source : AC1 3) chain A residue 135 type sequence L description BINDING SITE FOR RESIDUE C8D A 1181 source : AC1 4) chain A residue 137 type sequence G description BINDING SITE FOR RESIDUE C8D A 1181 source : AC1 5) chain A residue 139 type sequence S description BINDING SITE FOR RESIDUE C8D A 1181 source : AC1 6) chain A residue 154 type sequence F description BINDING SITE FOR RESIDUE C8D A 1181 source : AC1 7) chain A residue 155 type sequence R description BINDING SITE FOR RESIDUE C8D A 1181 source : AC1 8) chain A residue 156 type sequence A description BINDING SITE FOR RESIDUE C8D A 1181 source : AC1 9) chain A residue 157 type sequence A description BINDING SITE FOR RESIDUE C8D A 1181 source : AC1 10) chain A residue 168 type sequence D description BINDING SITE FOR RESIDUE C8D A 1181 source : AC1 11) chain B residue 57 type sequence H description BINDING SITE FOR RESIDUE C8D B 1181 source : AC2 12) chain B residue 81 type sequence D description BINDING SITE FOR RESIDUE C8D B 1181 source : AC2 13) chain B residue 123 type sequence R description BINDING SITE FOR RESIDUE C8D B 1181 source : AC2 14) chain B residue 139 type sequence S description BINDING SITE FOR RESIDUE C8D B 1181 source : AC2 15) chain B residue 155 type sequence R description BINDING SITE FOR RESIDUE C8D B 1181 source : AC2 16) chain B residue 156 type sequence A description BINDING SITE FOR RESIDUE C8D B 1181 source : AC2 17) chain B residue 157 type sequence A description BINDING SITE FOR RESIDUE C8D B 1181 source : AC2 18) chain B residue 161 type sequence R description BINDING SITE FOR RESIDUE C8D B 1181 source : AC2 19) chain B residue 168 type sequence D description BINDING SITE FOR RESIDUE C8D B 1181 source : AC2 20) chain A residue 4 type sequence T description BINDING SITE FOR RESIDUE MG C 1041 source : AC3 21) chain C residue 31 type sequence L description BINDING SITE FOR RESIDUE MG C 1041 source : AC3 22) chain C residue 33 type sequence G description BINDING SITE FOR RESIDUE MG C 1041 source : AC3 23) chain A residue 5 type sequence A description BINDING SITE FOR RESIDUE MG A 1182 source : AC4 24) chain A residue 111 type sequence A description BINDING SITE FOR RESIDUE MG A 1182 source : AC4 25) chain A residue 97 type sequence C description BINDING SITE FOR RESIDUE ZN A 1183 source : AC5 26) chain A residue 98 type sequence T description BINDING SITE FOR RESIDUE ZN A 1183 source : AC5 27) chain A residue 99 type sequence C description BINDING SITE FOR RESIDUE ZN A 1183 source : AC5 28) chain A residue 145 type sequence C description BINDING SITE FOR RESIDUE ZN A 1183 source : AC5 29) chain B residue 97 type sequence C description BINDING SITE FOR RESIDUE ZN B 1182 source : AC6 30) chain B residue 98 type sequence T description BINDING SITE FOR RESIDUE ZN B 1182 source : AC6 31) chain B residue 99 type sequence C description BINDING SITE FOR RESIDUE ZN B 1182 source : AC6 32) chain B residue 145 type sequence C description BINDING SITE FOR RESIDUE ZN B 1182 source : AC6

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