eF-site ID 2xbu-AB PDB Code 2xbu Chain A, B click to enlarge Title Saccharomyces cerevisiae hypoxanthine-guanine phosphoribosyltransferase in complex with GMP (monoclinic crystal form) Classification TRANSFERASE Compound HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE Source (HPRT_YEAST) Sequence A:  DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPA RILRTFLKEPGVPTIRIFAIILSLYEVKVSRTQWIDYEQC KLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAKAK GIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDKNR YFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIPEQ E B:  DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPA RILRTFLKEPGVPTIRIFAIILSLYEDLVKVSRTQWIDYE QCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAK AKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDK NRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIP EQE Description Functional site 1) chain A residue 60 type sequence R description BINDING SITE FOR RESIDUE ACT A 1219 source : AC1 2) chain A residue 114 type sequence D description BINDING SITE FOR RESIDUE 5GP A 1220 source : AC2 3) chain A residue 115 type sequence T description BINDING SITE FOR RESIDUE 5GP A 1220 source : AC2 4) chain A residue 116 type sequence R description BINDING SITE FOR RESIDUE 5GP A 1220 source : AC2 5) chain A residue 117 type sequence T description BINDING SITE FOR RESIDUE 5GP A 1220 source : AC2 6) chain A residue 118 type sequence T description BINDING SITE FOR RESIDUE 5GP A 1220 source : AC2 7) chain A residue 159 type sequence K description BINDING SITE FOR RESIDUE 5GP A 1220 source : AC2 8) chain A residue 188 type sequence W description BINDING SITE FOR RESIDUE 5GP A 1220 source : AC2 9) chain A residue 189 type sequence Y description BINDING SITE FOR RESIDUE 5GP A 1220 source : AC2 10) chain A residue 191 type sequence Y description BINDING SITE FOR RESIDUE 5GP A 1220 source : AC2 11) chain A residue 194 type sequence E description BINDING SITE FOR RESIDUE 5GP A 1220 source : AC2 12) chain B residue 36 type sequence I description BINDING SITE FOR RESIDUE MG B 301 source : AC3 13) chain B residue 40 type sequence G description BINDING SITE FOR RESIDUE MG B 301 source : AC3 14) chain B residue 110 type sequence D description BINDING SITE FOR RESIDUE MG B 301 source : AC3 15) chain B residue 111 type sequence E description BINDING SITE FOR RESIDUE MG B 301 source : AC3 16) chain B residue 60 type sequence R description BINDING SITE FOR RESIDUE ACT B 1219 source : AC4 17) chain B residue 104 type sequence K description BINDING SITE FOR RESIDUE ACT B 1219 source : AC4 18) chain B residue 114 type sequence D description BINDING SITE FOR RESIDUE 5GP B 1220 source : AC5 19) chain B residue 115 type sequence T description BINDING SITE FOR RESIDUE 5GP B 1220 source : AC5 20) chain B residue 116 type sequence R description BINDING SITE FOR RESIDUE 5GP B 1220 source : AC5 21) chain B residue 117 type sequence T description BINDING SITE FOR RESIDUE 5GP B 1220 source : AC5 22) chain B residue 118 type sequence T description BINDING SITE FOR RESIDUE 5GP B 1220 source : AC5 23) chain B residue 159 type sequence K description BINDING SITE FOR RESIDUE 5GP B 1220 source : AC5 24) chain B residue 188 type sequence W description BINDING SITE FOR RESIDUE 5GP B 1220 source : AC5 25) chain B residue 189 type sequence Y description BINDING SITE FOR RESIDUE 5GP B 1220 source : AC5 26) chain B residue 191 type sequence Y description BINDING SITE FOR RESIDUE 5GP B 1220 source : AC5 27) chain B residue 194 type sequence E description BINDING SITE FOR RESIDUE 5GP B 1220 source : AC5 28) chain A residue 114 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 114 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 85 type BINDING sequence K description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 110 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 159 type BINDING sequence K description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 188 type BINDING sequence W description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 85 type BINDING sequence K description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 110 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 159 type BINDING sequence K description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 188 type BINDING sequence W description BINDING => ECO:0000269|PubMed:18245832 source Swiss-Prot : SWS_FT_FI2

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