eF-site ID 2xba-A PDB Code 2xba Chain A click to enlarge Title Structure of Human Anaplastic Lymphoma Kinase in complex with PHA- E429 Classification TRANSFERASE Compound ALK TYROSINE KINASE RECEPTOR Source Homo sapiens (Human) (ALK_HUMAN) Sequence A:  NYCFAGKTSSISDLKEVPRKNITLIRGLVYEGQVSPLQVA VKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQ SLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLH VARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKI GDFGMARDIYAMLPVKWMPPEAFMEGIFTSKTDTWSFGVL LWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPV YRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALP IEYG Description (1)  ALK TYROSINE KINASE RECEPTOR (E.C.2.7.10.1) Functional site 1) chain A residue 1148 type sequence A description BINDING SITE FOR RESIDUE 571 A 1501 source : AC1 2) chain A residue 1150 type sequence K description BINDING SITE FOR RESIDUE 571 A 1501 source : AC1 3) chain A residue 1197 type sequence E description BINDING SITE FOR RESIDUE 571 A 1501 source : AC1 4) chain A residue 1198 type sequence L description BINDING SITE FOR RESIDUE 571 A 1501 source : AC1 5) chain A residue 1199 type sequence M description BINDING SITE FOR RESIDUE 571 A 1501 source : AC1 6) chain A residue 1200 type sequence A description BINDING SITE FOR RESIDUE 571 A 1501 source : AC1 7) chain A residue 1202 type sequence G description BINDING SITE FOR RESIDUE 571 A 1501 source : AC1 8) chain A residue 1210 type sequence E description BINDING SITE FOR RESIDUE 571 A 1501 source : AC1 9) chain A residue 1253 type sequence R description BINDING SITE FOR RESIDUE 571 A 1501 source : AC1 10) chain A residue 1254 type sequence N description BINDING SITE FOR RESIDUE 571 A 1501 source : AC1 11) chain A residue 1256 type sequence L description BINDING SITE FOR RESIDUE 571 A 1501 source : AC1 12) chain A residue 1278 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:15938644 source Swiss-Prot : SWS_FT_FI7 13) chain A residue 1197 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 14) chain A residue 1270 type BINDING sequence D description BINDING => ECO:0000269|PubMed:20632993 source Swiss-Prot : SWS_FT_FI4 15) chain A residue 1096 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:16878150, ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI5 16) chain A residue 1131 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI6 17) chain A residue 1122-1150 type prosite sequence LVYEGQVSPLQVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGHGAFGEVYeGqvsgmpndpsplq.....VAVK source prosite : PS00107 18) chain A residue 1245-1257 type prosite sequence FIHRDIAARNCLL description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDIAARNCLL source prosite : PS00109 19) chain A residue 1249 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 1150 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI3

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