eF-site ID 2xag-A PDB Code 2xag Chain A click to enlarge Title Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine Classification TRANSCRIPTION Compound LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 Source Homo sapiens (Human) (RCOR1_HUMAN) Sequence A:  PSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVF LFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVH RVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSG LAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLG AMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAV PKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQ ALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVN LKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTAL CKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILD WHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNG YSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRST SQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSA VQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGE LFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAI LKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSG NDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPAT VHGALLSGLREAGRIADQFLGAMYTL Description (1)  LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 (E.C.1.-.-.-), REST COREPRESSOR 1 Functional site 1) chain A residue 285 type sequence G description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 2) chain A residue 287 type sequence G description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 3) chain A residue 288 type sequence V description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 4) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 5) chain A residue 307 type sequence L description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 6) chain A residue 308 type sequence E description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 7) chain A residue 309 type sequence A description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 8) chain A residue 310 type sequence R description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 9) chain A residue 314 type sequence G description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 10) chain A residue 315 type sequence G description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 11) chain A residue 316 type sequence R description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 12) chain A residue 329 type sequence L description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 13) chain A residue 330 type sequence G description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 14) chain A residue 331 type sequence A description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 15) chain A residue 332 type sequence M description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 16) chain A residue 333 type sequence V description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 17) chain A residue 588 type sequence T description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 18) chain A residue 589 type sequence A description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 19) chain A residue 590 type sequence V description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 20) chain A residue 624 type sequence T description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 21) chain A residue 625 type sequence L description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 22) chain A residue 626 type sequence P description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 23) chain A residue 751 type sequence W description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 24) chain A residue 756 type sequence W description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 25) chain A residue 760 type sequence S description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 26) chain A residue 761 type sequence Y description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 27) chain A residue 800 type sequence G description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 28) chain A residue 801 type sequence E description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 29) chain A residue 809 type sequence A description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 30) chain A residue 810 type sequence T description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 31) chain A residue 811 type sequence V description BINDING SITE FOR RESIDUE FAD A 900 source : AC1 32) chain A residue 332 type sequence M description BINDING SITE FOR RESIDUE TCF A 901 source : AC2 33) chain A residue 335 type sequence T description BINDING SITE FOR RESIDUE TCF A 901 source : AC2 34) chain A residue 661 type sequence K description BINDING SITE FOR RESIDUE TCF A 901 source : AC2 35) chain A residue 761 type sequence Y description BINDING SITE FOR RESIDUE TCF A 901 source : AC2 36) chain A residue 809 type sequence A description BINDING SITE FOR RESIDUE TCF A 901 source : AC2 37) chain A residue 810 type sequence T description BINDING SITE FOR RESIDUE TCF A 901 source : AC2 38) chain A residue 442 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI11 39) chain A residue 469 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI11 40) chain A residue 503 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:25018020 source Swiss-Prot : SWS_FT_FI12 41) chain A residue 611 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI9 42) chain A residue 308 type MOD_RES sequence E description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 310 type MOD_RES sequence R description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 316 type MOD_RES sequence R description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 332 type MOD_RES sequence M description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 801 type MOD_RES sequence E description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 810 type MOD_RES sequence T description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1

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