eF-site ID 2xae-ABC PDB Code 2xae Chain A, B, C click to enlarge Title Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid Classification CELL CYCLE Compound KINESIN-LIKE PROTEIN KIF11 Source Homo sapiens (Human) (KIF11_HUMAN) Sequence A:  KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGG LADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMG YNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGII PRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSS DVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEK GAAKRTTAATLMNAYSSRSHSVFSVTIHMKEEELVKIGKL NLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKL TRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRA KNILNKPE B:  KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGG LADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMG YNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGII PRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSS DVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEK GAAKRTTAATLMNAYSSRSHSVFSVTIHMKEEELVKIGKL NLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKL TRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRA KNILNKPE C:  NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGL ADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGY NCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP RTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD VSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG AAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVK IGKLNLVDLAGSENNQSLLTLGRVITALVERTPHVPYRES KLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAH RAKNILNKP Description Functional site 1) chain A residue 116 type sequence E description BINDING SITE FOR RESIDUE 2XA A 1365 source : AC1 2) chain A residue 117 type sequence G description BINDING SITE FOR RESIDUE 2XA A 1365 source : AC1 3) chain A residue 118 type sequence E description BINDING SITE FOR RESIDUE 2XA A 1365 source : AC1 4) chain A residue 119 type sequence R description BINDING SITE FOR RESIDUE 2XA A 1365 source : AC1 5) chain A residue 133 type sequence A description BINDING SITE FOR RESIDUE 2XA A 1365 source : AC1 6) chain A residue 137 type sequence P description BINDING SITE FOR RESIDUE 2XA A 1365 source : AC1 7) chain A residue 211 type sequence Y description BINDING SITE FOR RESIDUE 2XA A 1365 source : AC1 8) chain A residue 214 type sequence L description BINDING SITE FOR RESIDUE 2XA A 1365 source : AC1 9) chain A residue 215 type sequence E description BINDING SITE FOR RESIDUE 2XA A 1365 source : AC1 10) chain A residue 221 type sequence R description BINDING SITE FOR RESIDUE 2XA A 1365 source : AC1 11) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE MG A 1366 source : AC2 12) chain A residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP A 1367 source : AC3 13) chain A residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP A 1367 source : AC3 14) chain A residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP A 1367 source : AC3 15) chain A residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP A 1367 source : AC3 16) chain A residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP A 1367 source : AC3 17) chain A residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP A 1367 source : AC3 18) chain A residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP A 1367 source : AC3 19) chain A residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP A 1367 source : AC3 20) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP A 1367 source : AC3 21) chain A residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP A 1367 source : AC3 22) chain A residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP A 1367 source : AC3 23) chain B residue 116 type sequence E description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 24) chain B residue 117 type sequence G description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 25) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 26) chain B residue 127 type sequence W description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 27) chain B residue 137 type sequence P description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 28) chain B residue 211 type sequence Y description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 29) chain B residue 214 type sequence L description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 30) chain B residue 221 type sequence R description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 31) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE MG B 1366 source : AC5 32) chain B residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 33) chain B residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 34) chain B residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 35) chain B residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 36) chain B residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 37) chain B residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 38) chain B residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 39) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 40) chain B residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 41) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 42) chain C residue 112 type sequence T description BINDING SITE FOR RESIDUE 2XA C 1364 source : AC7 43) chain C residue 116 type sequence E description BINDING SITE FOR RESIDUE 2XA C 1364 source : AC7 44) chain C residue 117 type sequence G description BINDING SITE FOR RESIDUE 2XA C 1364 source : AC7 45) chain C residue 118 type sequence E description BINDING SITE FOR RESIDUE 2XA C 1364 source : AC7 46) chain C residue 119 type sequence R description BINDING SITE FOR RESIDUE 2XA C 1364 source : AC7 47) chain C residue 211 type sequence Y description BINDING SITE FOR RESIDUE 2XA C 1364 source : AC7 48) chain C residue 214 type sequence L description BINDING SITE FOR RESIDUE 2XA C 1364 source : AC7 49) chain C residue 215 type sequence E description BINDING SITE FOR RESIDUE 2XA C 1364 source : AC7 50) chain C residue 112 type sequence T description BINDING SITE FOR RESIDUE MG C 1365 source : AC8 51) chain C residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP C 1366 source : AC9 52) chain C residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP C 1366 source : AC9 53) chain C residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP C 1366 source : AC9 54) chain C residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP C 1366 source : AC9 55) chain C residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP C 1366 source : AC9 56) chain C residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP C 1366 source : AC9 57) chain C residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP C 1366 source : AC9 58) chain C residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP C 1366 source : AC9 59) chain C residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP C 1366 source : AC9 60) chain C residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP C 1366 source : AC9 61) chain C residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP C 1366 source : AC9 62) chain B residue 184 type sequence M description BINDING SITE FOR RESIDUE SO4 B 1368 source : BC1 63) chain B residue 185 type sequence F description BINDING SITE FOR RESIDUE SO4 B 1368 source : BC1 64) chain B residue 186 type sequence D description BINDING SITE FOR RESIDUE SO4 B 1368 source : BC1 65) chain B residue 312 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1368 source : BC1 66) chain B residue 318 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1368 source : BC1 67) chain C residue 184 type sequence M description BINDING SITE FOR RESIDUE SO4 C 1367 source : BC2 68) chain C residue 185 type sequence F description BINDING SITE FOR RESIDUE SO4 C 1367 source : BC2 69) chain C residue 186 type sequence D description BINDING SITE FOR RESIDUE SO4 C 1367 source : BC2 70) chain C residue 312 type sequence R description BINDING SITE FOR RESIDUE SO4 C 1367 source : BC2 71) chain C residue 318 type sequence R description BINDING SITE FOR RESIDUE SO4 C 1367 source : BC2 72) chain B residue 42 type sequence E description BINDING SITE FOR RESIDUE SO4 B 1369 source : BC3 73) chain B residue 43 type sequence C description BINDING SITE FOR RESIDUE SO4 B 1369 source : BC3 74) chain B residue 74 type sequence A description BINDING SITE FOR RESIDUE SO4 B 1369 source : BC3 75) chain A residue 30 type sequence L description BINDING SITE FOR RESIDUE CL A 1368 source : BC4 76) chain A residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 77) chain B residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 78) chain C residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 79) chain A residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 80) chain B residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 81) chain C residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 82) chain A residue 259-270 type prosite sequence GKLNLVDLAGSE description KINESIN_MOTOR_1 Kinesin motor domain signature. GKLnLVDLAGSE source prosite : PS00411

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