eF-site ID 2xae-B PDB Code 2xae Chain B click to enlarge Title Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid Classification CELL CYCLE Compound KINESIN-LIKE PROTEIN KIF11 Source Homo sapiens (Human) (KIF11_HUMAN) Sequence B:  KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGG LADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMG YNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGII PRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSS DVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEK GAAKRTTAATLMNAYSSRSHSVFSVTIHMKEEELVKIGKL NLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKL TRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRA KNILNKPE Description Functional site 1) chain B residue 116 type sequence E description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 2) chain B residue 117 type sequence G description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 3) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 4) chain B residue 127 type sequence W description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 5) chain B residue 137 type sequence P description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 6) chain B residue 211 type sequence Y description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 7) chain B residue 214 type sequence L description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 8) chain B residue 221 type sequence R description BINDING SITE FOR RESIDUE 2XA B 1365 source : AC4 9) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE MG B 1366 source : AC5 10) chain B residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 11) chain B residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 12) chain B residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 13) chain B residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 14) chain B residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 15) chain B residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 16) chain B residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 17) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 18) chain B residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 19) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP B 1367 source : AC6 20) chain B residue 184 type sequence M description BINDING SITE FOR RESIDUE SO4 B 1368 source : BC1 21) chain B residue 185 type sequence F description BINDING SITE FOR RESIDUE SO4 B 1368 source : BC1 22) chain B residue 186 type sequence D description BINDING SITE FOR RESIDUE SO4 B 1368 source : BC1 23) chain B residue 312 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1368 source : BC1 24) chain B residue 318 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1368 source : BC1 25) chain B residue 42 type sequence E description BINDING SITE FOR RESIDUE SO4 B 1369 source : BC3 26) chain B residue 43 type sequence C description BINDING SITE FOR RESIDUE SO4 B 1369 source : BC3 27) chain B residue 74 type sequence A description BINDING SITE FOR RESIDUE SO4 B 1369 source : BC3 28) chain B residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2

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