eF-site ID 2x7h-A PDB Code 2x7h Chain A click to enlarge Title Crystal structure of the human MGC45594 gene product in complex with fenoprofen Classification OXIDOREDUCTASE Compound ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 Source Homo sapiens (Human) (ZADH2_HUMAN) Sequence A:  IPQAMQKLVVTRLSPNFREAVTLSRDCPVPLPGDGDLLVR NRFVGVNASDINYSAGRYDPSVKPPFDIGFEGIGEVVALG LSASARYTVGQAVAYMAPGSFAEYTVVPASIATPVPSVKP EYLTLLVSGTTAYISLKELGGLSEGKKVLVTAAAGGTGQF AMQLSKKAKCHVIGTCSSDEKSAFLKSLGCDRPINYKTEP VGTVLKQEYPEGVDVVYESVGGAMFDLAVDALATKGRLIV IGFISGYQTPTGLSPVKAGTLPAKLLKKSASVQGFFLNHY LSKYQAAMSHLLEMCVSGDLVCEVDLGDLSPEGRFTGLES IFRAVNYMYMGKNTGKIVVELPH Description Functional site 1) chain A residue 161 type sequence Y description BINDING SITE FOR RESIDUE PFN A 1372 source : AC1 2) chain A residue 192 type sequence L description BINDING SITE FOR RESIDUE PFN A 1372 source : AC1 3) chain A residue 318 type sequence H description BINDING SITE FOR RESIDUE PFN A 1372 source : AC1 4) chain A residue 76 type sequence A description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 5) chain A residue 159 type sequence T description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 6) chain A residue 180 type sequence A description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 7) chain A residue 183 type sequence G description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 8) chain A residue 184 type sequence G description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 9) chain A residue 185 type sequence T description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 10) chain A residue 204 type sequence C description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 11) chain A residue 205 type sequence S description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 12) chain A residue 209 type sequence K description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 13) chain A residue 224 type sequence Y description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 14) chain A residue 247 type sequence S description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 15) chain A residue 248 type sequence V description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 16) chain A residue 269 type sequence I description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 17) chain A residue 270 type sequence G description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 18) chain A residue 271 type sequence F description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 19) chain A residue 272 type sequence I description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 20) chain A residue 273 type sequence S description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 21) chain A residue 275 type sequence Y description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 22) chain A residue 303 type sequence F description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 23) chain A residue 305 type sequence L description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 24) chain A residue 356 type sequence M description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 25) chain A residue 361 type sequence N description BINDING SITE FOR RESIDUE NAP A 1373 source : AC2 26) chain A residue 144 type sequence P description BINDING SITE FOR RESIDUE PFN A 1374 source : AC3 27) chain A residue 145 type sequence S description BINDING SITE FOR RESIDUE PFN A 1374 source : AC3 28) chain A residue 147 type sequence K description BINDING SITE FOR RESIDUE PFN A 1374 source : AC3 29) chain A residue 150 type sequence Y description BINDING SITE FOR RESIDUE PFN A 1374 source : AC3 30) chain A residue 323 type sequence C description BINDING SITE FOR RESIDUE PFN A 1374 source : AC3 31) chain A residue 77 type sequence S description BINDING SITE FOR RESIDUE PFN A 1375 source : AC4 32) chain A residue 86 type sequence Y description BINDING SITE FOR RESIDUE PFN A 1375 source : AC4 33) chain A residue 155 type sequence V description BINDING SITE FOR RESIDUE PFN A 1375 source : AC4 34) chain A residue 275 type sequence Y description BINDING SITE FOR RESIDUE PFN A 1375 source : AC4 35) chain A residue 143 type sequence V description BINDING SITE FOR RESIDUE PFN A 1376 source : AC5 36) chain A residue 144 type sequence P description BINDING SITE FOR RESIDUE PFN A 1376 source : AC5 37) chain A residue 320 type sequence L description BINDING SITE FOR RESIDUE PFN A 1376 source : AC5 38) chain A residue 321 type sequence E description BINDING SITE FOR RESIDUE PFN A 1376 source : AC5 39) chain A residue 168 type sequence G description BINDING SITE FOR RESIDUE EDO A 1377 source : AC6 40) chain A residue 169 type sequence G description BINDING SITE FOR RESIDUE EDO A 1377 source : AC6 41) chain A residue 174 type sequence K description BINDING SITE FOR RESIDUE EDO A 1377 source : AC6 42) chain A residue 242 type sequence D description BINDING SITE FOR RESIDUE EDO A 1377 source : AC6 43) chain A residue 263 type sequence K description BINDING SITE FOR RESIDUE EDO A 1377 source : AC6 44) chain A residue 271 type sequence F description BINDING SITE FOR RESIDUE EDO A 1379 source : AC8 45) chain A residue 281 type sequence L description BINDING SITE FOR RESIDUE EDO A 1379 source : AC8 46) chain A residue 282 type sequence S description BINDING SITE FOR RESIDUE EDO A 1379 source : AC8 47) chain A residue 145 type sequence S description BINDING SITE FOR RESIDUE EDO A 1381 source : BC1 48) chain A residue 147 type sequence K description BINDING SITE FOR RESIDUE EDO A 1381 source : BC1 49) chain A residue 278 type sequence P description BINDING SITE FOR RESIDUE EDO A 1381 source : BC1 50) chain A residue 81 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1382 source : BC2 51) chain A residue 84 type sequence G description BINDING SITE FOR RESIDUE EDO A 1382 source : BC2 52) chain A residue 85 type sequence R description BINDING SITE FOR RESIDUE EDO A 1382 source : BC2 53) chain A residue 86 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1382 source : BC2 54) chain A residue 87 type sequence D description BINDING SITE FOR RESIDUE EDO A 1382 source : BC2 55) chain A residue 94 type sequence F description BINDING SITE FOR RESIDUE EDO A 1382 source : BC2 56) chain A residue 43 type sequence P description BINDING SITE FOR RESIDUE EDO A 1383 source : BC3 57) chain A residue 44 type sequence N description BINDING SITE FOR RESIDUE EDO A 1383 source : BC3 58) chain A residue 45 type sequence F description BINDING SITE FOR RESIDUE EDO A 1383 source : BC3 59) chain A residue 276 type sequence Q description BINDING SITE FOR RESIDUE EDO A 1383 source : BC3 60) chain A residue 354 type sequence N description BINDING SITE FOR RESIDUE EDO A 1383 source : BC3 61) chain A residue 230 type sequence G description BINDING SITE FOR RESIDUE EDO A 1384 source : BC4 62) chain A residue 233 type sequence L description BINDING SITE FOR RESIDUE EDO A 1384 source : BC4 63) chain A residue 234 type sequence K description BINDING SITE FOR RESIDUE EDO A 1384 source : BC4 64) chain A residue 237 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1384 source : BC4 65) chain A residue 259 type sequence A description BINDING SITE FOR RESIDUE EDO A 1384 source : BC4 66) chain A residue 253 type sequence F description BINDING SITE FOR RESIDUE EDO A 1385 source : BC5 67) chain A residue 254 type sequence D description BINDING SITE FOR RESIDUE EDO A 1385 source : BC5 68) chain A residue 257 type sequence V description BINDING SITE FOR RESIDUE EDO A 1385 source : BC5 69) chain A residue 258 type sequence D description BINDING SITE FOR RESIDUE EDO A 1385 source : BC5 70) chain A residue 285 type sequence K description BINDING SITE FOR RESIDUE EDO A 1385 source : BC5 71) chain A residue 286 type sequence A description BINDING SITE FOR RESIDUE EDO A 1385 source : BC5 72) chain A residue 292 type sequence K description BINDING SITE FOR RESIDUE EDO A 1385 source : BC5 73) chain A residue 185 type BINDING sequence T description BINDING => ECO:0000269|Ref.9 source Swiss-Prot : SWS_FT_FI1 74) chain A residue 205 type BINDING sequence S description BINDING => ECO:0000269|Ref.9 source Swiss-Prot : SWS_FT_FI1 75) chain A residue 209 type BINDING sequence K description BINDING => ECO:0000269|Ref.9 source Swiss-Prot : SWS_FT_FI1 76) chain A residue 224 type BINDING sequence Y description BINDING => ECO:0000269|Ref.9 source Swiss-Prot : SWS_FT_FI1 77) chain A residue 247 type BINDING sequence S description BINDING => ECO:0000269|Ref.9 source Swiss-Prot : SWS_FT_FI1 78) chain A residue 269 type BINDING sequence I description BINDING => ECO:0000269|Ref.9 source Swiss-Prot : SWS_FT_FI1 79) chain A residue 275 type BINDING sequence Y description BINDING => ECO:0000269|Ref.9 source Swiss-Prot : SWS_FT_FI1 80) chain A residue 303 type BINDING sequence F description BINDING => ECO:0000269|Ref.9 source Swiss-Prot : SWS_FT_FI1 81) chain A residue 361 type BINDING sequence N description BINDING => ECO:0000269|Ref.9 source Swiss-Prot : SWS_FT_FI1 82) chain A residue 173-194 type prosite sequence GKKVLVTAAAGGTGQFAMQLSK description QOR_ZETA_CRYSTAL Quinone oxidoreductase / zeta-crystallin signature. GKkvLvtaAAGGtGqfamQlsK source prosite : PS01162 83) chain A residue 35 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:Q8BGC4 source Swiss-Prot : SWS_FT_FI2 84) chain A residue 299 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3

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