eF-site ID 2x7g-A
PDB Code 2x7g
Chain A

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Title Structure of human serine-arginine-rich protein-specific kinase 2 (SRPK2) bound to purvalanol B
Classification TRANSFERASE
Compound UNCHARACTERIZED PROTEIN SRPK2
Source (C9JQJ0_HUMAN)
Sequence A:  PVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM
KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLI
DDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRC
VKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV
RRMAAELLVNPLDPRNADKIRVKIADLGNACWVHKHFTED
IQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLF
EPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFF
NRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLI
PMLEMVPEKRASAGECLRHPWLNS
Description


Functional site

1) chain A
residue 98
type
sequence L
description BINDING SITE FOR RESIDUE PVB A 800
source : AC1

2) chain A
residue 100
type
sequence W
description BINDING SITE FOR RESIDUE PVB A 800
source : AC1

3) chain A
residue 101
type
sequence G
description BINDING SITE FOR RESIDUE PVB A 800
source : AC1

4) chain A
residue 119
type
sequence A
description BINDING SITE FOR RESIDUE PVB A 800
source : AC1

5) chain A
residue 178
type
sequence E
description BINDING SITE FOR RESIDUE PVB A 800
source : AC1

6) chain A
residue 180
type
sequence L
description BINDING SITE FOR RESIDUE PVB A 800
source : AC1

7) chain A
residue 182
type
sequence H
description BINDING SITE FOR RESIDUE PVB A 800
source : AC1

8) chain A
residue 183
type
sequence H
description BINDING SITE FOR RESIDUE PVB A 800
source : AC1

9) chain A
residue 232
type
sequence L
description BINDING SITE FOR RESIDUE PVB A 800
source : AC1

10) chain A
residue 239
type
sequence Y
description BINDING SITE FOR RESIDUE PVB A 800
source : AC1

11) chain A
residue 593
type
sequence Y
description BINDING SITE FOR RESIDUE SO4 A 1700
source : AC2

12) chain A
residue 632
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1700
source : AC2

13) chain A
residue 636
type
sequence N
description BINDING SITE FOR RESIDUE SO4 A 1700
source : AC2

14) chain A
residue 637
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1700
source : AC2

15) chain A
residue 642
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1700
source : AC2

16) chain A
residue 687
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 1701
source : AC3

17) chain A
residue 689
type
sequence G
description BINDING SITE FOR RESIDUE SO4 A 1701
source : AC3

18) chain A
residue 693
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1701
source : AC3

19) chain A
residue 101
type
sequence G
description BINDING SITE FOR RESIDUE SO4 A 1702
source : AC4

20) chain A
residue 102
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 1702
source : AC4

21) chain A
residue 103
type
sequence F
description BINDING SITE FOR RESIDUE SO4 A 1702
source : AC4

22) chain A
residue 104
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 1702
source : AC4

23) chain A
residue 559
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1703
source : AC5

24) chain A
residue 562
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1703
source : AC5

25) chain A
residue 605
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1703
source : AC5

26) chain A
residue 598
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 1704
source : AC6

27) chain A
residue 599
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 1704
source : AC6

28) chain A
residue 605
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1704
source : AC6

29) chain A
residue 622
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1704
source : AC6

30) chain A
residue 622
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1705
source : AC7

31) chain A
residue 623
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 1705
source : AC7

32) chain A
residue 605
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1706
source : AC8

33) chain A
residue 637
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1706
source : AC8

34) chain A
residue 638
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 1706
source : AC8

35) chain A
residue 560
type
sequence Q
description BINDING SITE FOR RESIDUE ACT A 1707
source : AC9

36) chain A
residue 637
type
sequence R
description BINDING SITE FOR RESIDUE ACT A 1707
source : AC9

37) chain A
residue 136
type
sequence E
description BINDING SITE FOR RESIDUE EDO A 1708
source : BC1

38) chain A
residue 540
type
sequence A
description BINDING SITE FOR RESIDUE EDO A 1708
source : BC1

39) chain A
residue 541
type
sequence D
description BINDING SITE FOR RESIDUE EDO A 1708
source : BC1

40) chain A
residue 542
type
sequence L
description BINDING SITE FOR RESIDUE EDO A 1708
source : BC1

41) chain A
residue 150
type
sequence D
description BINDING SITE FOR RESIDUE EDO A 1709
source : BC2

42) chain A
residue 152
type
sequence N
description BINDING SITE FOR RESIDUE EDO A 1709
source : BC2

43) chain A
residue 213
type
sequence D
description BINDING SITE FOR RESIDUE EDO A 1709
source : BC2

44) chain A
residue 166
type
sequence S
description BINDING SITE FOR RESIDUE EDO A 1710
source : BC3

45) chain A
residue 651
type
sequence S
description BINDING SITE FOR RESIDUE EDO A 1710
source : BC3

46) chain A
residue 653
type
sequence F
description BINDING SITE FOR RESIDUE EDO A 1710
source : BC3

47) chain A
residue 671
type
sequence T
description BINDING SITE FOR RESIDUE EDO A 1710
source : BC3

48) chain A
residue 594
type
sequence L
description BINDING SITE FOR RESIDUE EDO A 1711
source : BC4

49) chain A
residue 163
type
sequence F
description BINDING SITE FOR RESIDUE EDO A 1712
source : BC5

50) chain A
residue 164
type
sequence K
description BINDING SITE FOR RESIDUE EDO A 1712
source : BC5

51) chain A
residue 649
type
sequence P
description BINDING SITE FOR RESIDUE EDO A 1712
source : BC5

52) chain A
residue 650
type
sequence W
description BINDING SITE FOR RESIDUE EDO A 1712
source : BC5

53) chain A
residue 651
type
sequence S
description BINDING SITE FOR RESIDUE EDO A 1712
source : BC5

54) chain A
residue 654
type
sequence D
description BINDING SITE FOR RESIDUE EDO A 1712
source : BC5

55) chain A
residue 164
type
sequence K
description BINDING SITE FOR RESIDUE EDO A 1713
source : BC6

56) chain A
residue 616
type
sequence L
description BINDING SITE FOR RESIDUE EDO A 1713
source : BC6

57) chain A
residue 649
type
sequence P
description BINDING SITE FOR RESIDUE EDO A 1713
source : BC6

58) chain A
residue 98-121
type prosite
sequence LGWGHFSTVWLCWDMQGKRFVAMK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGWGHFSTVWlCwdmqgkrf..........VAMK
source prosite : PS00107

59) chain A
residue 221-233
type prosite
sequence IIHTDIKPENILM
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHtDIKpeNILM
source prosite : PS00108

60) chain A
residue 225
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
source Swiss-Prot : SWS_FT_FI1

61) chain A
residue 98
type BINDING
sequence L
description BINDING => ECO:0000250|UniProtKB:Q9UPE1, ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

62) chain A
residue 121
type BINDING
sequence K
description BINDING => ECO:0000250|UniProtKB:Q9UPE1, ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

63) chain A
residue 150
type SITE
sequence D
description Cleavage; by caspase-3 => ECO:0000269|PubMed:21056976
source Swiss-Prot : SWS_FT_FI3

64) chain A
residue 665
type SITE
sequence E
description Cleavage; by caspase-3 => ECO:0000269|PubMed:21056976
source Swiss-Prot : SWS_FT_FI3

65) chain A
residue 642
type MOD_RES
sequence R
description Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI5


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