eF-site ID 2x7g-A PDB Code 2x7g Chain A click to enlarge Title Structure of human serine-arginine-rich protein-specific kinase 2 (SRPK2) bound to purvalanol B Classification TRANSFERASE Compound UNCHARACTERIZED PROTEIN SRPK2 Source (C9JQJ0_HUMAN) Sequence A:  PVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLI DDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRC VKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV RRMAAELLVNPLDPRNADKIRVKIADLGNACWVHKHFTED IQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLF EPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFF NRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLI PMLEMVPEKRASAGECLRHPWLNS Description Functional site 1) chain A residue 98 type sequence L description BINDING SITE FOR RESIDUE PVB A 800 source : AC1 2) chain A residue 100 type sequence W description BINDING SITE FOR RESIDUE PVB A 800 source : AC1 3) chain A residue 101 type sequence G description BINDING SITE FOR RESIDUE PVB A 800 source : AC1 4) chain A residue 119 type sequence A description BINDING SITE FOR RESIDUE PVB A 800 source : AC1 5) chain A residue 178 type sequence E description BINDING SITE FOR RESIDUE PVB A 800 source : AC1 6) chain A residue 180 type sequence L description BINDING SITE FOR RESIDUE PVB A 800 source : AC1 7) chain A residue 182 type sequence H description BINDING SITE FOR RESIDUE PVB A 800 source : AC1 8) chain A residue 183 type sequence H description BINDING SITE FOR RESIDUE PVB A 800 source : AC1 9) chain A residue 232 type sequence L description BINDING SITE FOR RESIDUE PVB A 800 source : AC1 10) chain A residue 239 type sequence Y description BINDING SITE FOR RESIDUE PVB A 800 source : AC1 11) chain A residue 593 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1700 source : AC2 12) chain A residue 632 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1700 source : AC2 13) chain A residue 636 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1700 source : AC2 14) chain A residue 637 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1700 source : AC2 15) chain A residue 642 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1700 source : AC2 16) chain A residue 687 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1701 source : AC3 17) chain A residue 689 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1701 source : AC3 18) chain A residue 693 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1701 source : AC3 19) chain A residue 101 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1702 source : AC4 20) chain A residue 102 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1702 source : AC4 21) chain A residue 103 type sequence F description BINDING SITE FOR RESIDUE SO4 A 1702 source : AC4 22) chain A residue 104 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1702 source : AC4 23) chain A residue 559 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1703 source : AC5 24) chain A residue 562 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1703 source : AC5 25) chain A residue 605 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1703 source : AC5 26) chain A residue 598 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1704 source : AC6 27) chain A residue 599 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1704 source : AC6 28) chain A residue 605 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1704 source : AC6 29) chain A residue 622 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1704 source : AC6 30) chain A residue 622 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1705 source : AC7 31) chain A residue 623 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1705 source : AC7 32) chain A residue 605 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1706 source : AC8 33) chain A residue 637 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1706 source : AC8 34) chain A residue 638 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1706 source : AC8 35) chain A residue 560 type sequence Q description BINDING SITE FOR RESIDUE ACT A 1707 source : AC9 36) chain A residue 637 type sequence R description BINDING SITE FOR RESIDUE ACT A 1707 source : AC9 37) chain A residue 136 type sequence E description BINDING SITE FOR RESIDUE EDO A 1708 source : BC1 38) chain A residue 540 type sequence A description BINDING SITE FOR RESIDUE EDO A 1708 source : BC1 39) chain A residue 541 type sequence D description BINDING SITE FOR RESIDUE EDO A 1708 source : BC1 40) chain A residue 542 type sequence L description BINDING SITE FOR RESIDUE EDO A 1708 source : BC1 41) chain A residue 150 type sequence D description BINDING SITE FOR RESIDUE EDO A 1709 source : BC2 42) chain A residue 152 type sequence N description BINDING SITE FOR RESIDUE EDO A 1709 source : BC2 43) chain A residue 213 type sequence D description BINDING SITE FOR RESIDUE EDO A 1709 source : BC2 44) chain A residue 166 type sequence S description BINDING SITE FOR RESIDUE EDO A 1710 source : BC3 45) chain A residue 651 type sequence S description BINDING SITE FOR RESIDUE EDO A 1710 source : BC3 46) chain A residue 653 type sequence F description BINDING SITE FOR RESIDUE EDO A 1710 source : BC3 47) chain A residue 671 type sequence T description BINDING SITE FOR RESIDUE EDO A 1710 source : BC3 48) chain A residue 594 type sequence L description BINDING SITE FOR RESIDUE EDO A 1711 source : BC4 49) chain A residue 163 type sequence F description BINDING SITE FOR RESIDUE EDO A 1712 source : BC5 50) chain A residue 164 type sequence K description BINDING SITE FOR RESIDUE EDO A 1712 source : BC5 51) chain A residue 649 type sequence P description BINDING SITE FOR RESIDUE EDO A 1712 source : BC5 52) chain A residue 650 type sequence W description BINDING SITE FOR RESIDUE EDO A 1712 source : BC5 53) chain A residue 651 type sequence S description BINDING SITE FOR RESIDUE EDO A 1712 source : BC5 54) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE EDO A 1712 source : BC5 55) chain A residue 164 type sequence K description BINDING SITE FOR RESIDUE EDO A 1713 source : BC6 56) chain A residue 616 type sequence L description BINDING SITE FOR RESIDUE EDO A 1713 source : BC6 57) chain A residue 649 type sequence P description BINDING SITE FOR RESIDUE EDO A 1713 source : BC6 58) chain A residue 98-121 type prosite sequence LGWGHFSTVWLCWDMQGKRFVAMK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGWGHFSTVWlCwdmqgkrf..........VAMK source prosite : PS00107 59) chain A residue 221-233 type prosite sequence IIHTDIKPENILM description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHtDIKpeNILM source prosite : PS00108 60) chain A residue 225 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 61) chain A residue 98 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:Q9UPE1, ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 62) chain A residue 121 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:Q9UPE1, ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 63) chain A residue 150 type SITE sequence D description Cleavage; by caspase-3 => ECO:0000269|PubMed:21056976 source Swiss-Prot : SWS_FT_FI3 64) chain A residue 665 type SITE sequence E description Cleavage; by caspase-3 => ECO:0000269|PubMed:21056976 source Swiss-Prot : SWS_FT_FI3 65) chain A residue 642 type MOD_RES sequence R description Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5

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