eF-site ID 2x6j-B PDB Code 2x6j Chain B click to enlarge Title THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-93 Classification TRANSFERASE Compound PHOSPHOTIDYLINOSITOL 3 KINASE 59F Source Drosophila melanogaster (Fruit fly) (Q9W1M7_DROME) Sequence B:  ASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKK ALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLS PTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDP RHIVHLHGCIFPEANLCTFLIQRACTNATLANYFYWYLSI EVEKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRK QRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFK VNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLT FVTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRE NLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIH NFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGV GDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSK EMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFS LMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQS LLDVSITAVMPALVEQIHRFTQYWRK Description Functional site 1) chain B residue 675 type sequence S description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 2) chain B residue 679 type sequence P description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 3) chain B residue 698 type sequence K description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 4) chain B residue 732 type sequence Y description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 5) chain B residue 744 type sequence L description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 6) chain B residue 745 type sequence Q description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 7) chain B residue 746 type sequence Y description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 8) chain B residue 747 type sequence V description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 9) chain B residue 749 type sequence S description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 10) chain B residue 822 type sequence I description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 11) chain B residue 823 type sequence D description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2

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