eF-site ID 2x6j-AB PDB Code 2x6j Chain A, B click to enlarge Title THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-93 Classification TRANSFERASE Compound PHOSPHOTIDYLINOSITOL 3 KINASE 59F Source Drosophila melanogaster (Fruit fly) (Q9W1M7_DROME) Sequence A:  ASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKK ALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLS PTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDP RHIVHLHGCIFPANLCTFLIQRACTNATLANYFYWYLSIE VEEKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRK QRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFK VNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLT FVTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRE NLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIH NFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGV GDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSK EMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFS LMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQS LLDVSITAVMPALVEQIHRFTQYWR B:  ASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKK ALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLS PTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDP RHIVHLHGCIFPEANLCTFLIQRACTNATLANYFYWYLSI EVEKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRK QRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFK VNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLT FVTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRE NLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIH NFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGV GDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSK EMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFS LMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQS LLDVSITAVMPALVEQIHRFTQYWRK Description Functional site 1) chain A residue 679 type sequence P description BINDING SITE FOR RESIDUE 093 A 1949 source : AC1 2) chain A residue 698 type sequence K description BINDING SITE FOR RESIDUE 093 A 1949 source : AC1 3) chain A residue 744 type sequence L description BINDING SITE FOR RESIDUE 093 A 1949 source : AC1 4) chain A residue 745 type sequence Q description BINDING SITE FOR RESIDUE 093 A 1949 source : AC1 5) chain A residue 746 type sequence Y description BINDING SITE FOR RESIDUE 093 A 1949 source : AC1 6) chain A residue 747 type sequence V description BINDING SITE FOR RESIDUE 093 A 1949 source : AC1 7) chain A residue 749 type sequence S description BINDING SITE FOR RESIDUE 093 A 1949 source : AC1 8) chain A residue 822 type sequence I description BINDING SITE FOR RESIDUE 093 A 1949 source : AC1 9) chain A residue 823 type sequence D description BINDING SITE FOR RESIDUE 093 A 1949 source : AC1 10) chain B residue 675 type sequence S description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 11) chain B residue 679 type sequence P description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 12) chain B residue 698 type sequence K description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 13) chain B residue 732 type sequence Y description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 14) chain B residue 744 type sequence L description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 15) chain B residue 745 type sequence Q description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 16) chain B residue 746 type sequence Y description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 17) chain B residue 747 type sequence V description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 18) chain B residue 749 type sequence S description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 19) chain B residue 822 type sequence I description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 20) chain B residue 823 type sequence D description BINDING SITE FOR RESIDUE 093 B 1950 source : AC2 21) chain A residue 697-711 type prosite sequence FKHGDDLRQDQLILQ description PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDqlilQ source prosite : PS00915 22) chain A residue 790-810 type prosite sequence SCAGYCVITYLLGVGDRHLDN description PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVitYLLgVgDRHldN source prosite : PS00916

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