eF-site ID 2x2r-ABC PDB Code 2x2r Chain A, B, C click to enlarge Title Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid Classification CELL CYCLE Compound KINESIN-LIKE PROTEIN KIF11 Source Homo sapiens (Human) (KIF11_HUMAN) Sequence A:  KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGG LADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMG YNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGII PRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSS DVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEK GAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELV KIGKLNLVDLAGSENQSLLTLGRVITALVERTPHVPYRES KLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAH RAKNILNKPEV B:  KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGG LADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMG YNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGII PRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSS DVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEK GAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTLVKIGKL NLVDLAGSENQSLLTLGRVITALVERTPHVPYRESKLTRI LQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNI LNKP C:  NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGL ADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGY NCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP RTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD VSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG AAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVK IGKLNLVDLAGSENNQSLLTLGRVITALVERTPHVPYRES KLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAH RAKNILNKP Description Functional site 1) chain A residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP A 1366 source : AC1 2) chain A residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP A 1366 source : AC1 3) chain A residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP A 1366 source : AC1 4) chain A residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP A 1366 source : AC1 5) chain A residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP A 1366 source : AC1 6) chain A residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP A 1366 source : AC1 7) chain A residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP A 1366 source : AC1 8) chain A residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP A 1366 source : AC1 9) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP A 1366 source : AC1 10) chain A residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP A 1366 source : AC1 11) chain A residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP A 1366 source : AC1 12) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE X2O A 1367 source : AC2 13) chain A residue 116 type sequence E description BINDING SITE FOR RESIDUE X2O A 1367 source : AC2 14) chain A residue 117 type sequence G description BINDING SITE FOR RESIDUE X2O A 1367 source : AC2 15) chain A residue 118 type sequence E description BINDING SITE FOR RESIDUE X2O A 1367 source : AC2 16) chain A residue 119 type sequence R description BINDING SITE FOR RESIDUE X2O A 1367 source : AC2 17) chain A residue 137 type sequence P description BINDING SITE FOR RESIDUE X2O A 1367 source : AC2 18) chain A residue 211 type sequence Y description BINDING SITE FOR RESIDUE X2O A 1367 source : AC2 19) chain A residue 214 type sequence L description BINDING SITE FOR RESIDUE X2O A 1367 source : AC2 20) chain A residue 221 type sequence R description BINDING SITE FOR RESIDUE X2O A 1367 source : AC2 21) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE MG A 1368 source : AC3 22) chain B residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP B 1366 source : AC4 23) chain B residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP B 1366 source : AC4 24) chain B residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP B 1366 source : AC4 25) chain B residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP B 1366 source : AC4 26) chain B residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP B 1366 source : AC4 27) chain B residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP B 1366 source : AC4 28) chain B residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP B 1366 source : AC4 29) chain B residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP B 1366 source : AC4 30) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP B 1366 source : AC4 31) chain B residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP B 1366 source : AC4 32) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP B 1366 source : AC4 33) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE MG B 1368 source : AC5 34) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE X2O B 1367 source : AC6 35) chain B residue 116 type sequence E description BINDING SITE FOR RESIDUE X2O B 1367 source : AC6 36) chain B residue 117 type sequence G description BINDING SITE FOR RESIDUE X2O B 1367 source : AC6 37) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE X2O B 1367 source : AC6 38) chain B residue 137 type sequence P description BINDING SITE FOR RESIDUE X2O B 1367 source : AC6 39) chain B residue 211 type sequence Y description BINDING SITE FOR RESIDUE X2O B 1367 source : AC6 40) chain B residue 214 type sequence L description BINDING SITE FOR RESIDUE X2O B 1367 source : AC6 41) chain B residue 221 type sequence R description BINDING SITE FOR RESIDUE X2O B 1367 source : AC6 42) chain C residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP C 1366 source : AC7 43) chain C residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP C 1366 source : AC7 44) chain C residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP C 1366 source : AC7 45) chain C residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP C 1366 source : AC7 46) chain C residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP C 1366 source : AC7 47) chain C residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP C 1366 source : AC7 48) chain C residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP C 1366 source : AC7 49) chain C residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP C 1366 source : AC7 50) chain C residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP C 1366 source : AC7 51) chain C residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP C 1366 source : AC7 52) chain C residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP C 1366 source : AC7 53) chain C residue 112 type sequence T description BINDING SITE FOR RESIDUE MG C 1368 source : AC8 54) chain C residue 112 type sequence T description BINDING SITE FOR RESIDUE X2O C 1367 source : AC9 55) chain C residue 116 type sequence E description BINDING SITE FOR RESIDUE X2O C 1367 source : AC9 56) chain C residue 117 type sequence G description BINDING SITE FOR RESIDUE X2O C 1367 source : AC9 57) chain C residue 118 type sequence E description BINDING SITE FOR RESIDUE X2O C 1367 source : AC9 58) chain C residue 137 type sequence P description BINDING SITE FOR RESIDUE X2O C 1367 source : AC9 59) chain C residue 211 type sequence Y description BINDING SITE FOR RESIDUE X2O C 1367 source : AC9 60) chain C residue 214 type sequence L description BINDING SITE FOR RESIDUE X2O C 1367 source : AC9 61) chain C residue 221 type sequence R description BINDING SITE FOR RESIDUE X2O C 1367 source : AC9 62) chain A residue 259-270 type prosite sequence GKLNLVDLAGSE description KINESIN_MOTOR_1 Kinesin motor domain signature. GKLnLVDLAGSE source prosite : PS00411 63) chain A residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 64) chain B residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 65) chain C residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 66) chain A residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 67) chain B residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 68) chain C residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2

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