eF-site ID 2x1t-AB PDB Code 2x1t Chain A, B click to enlarge Title Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase Classification ISOMERASE Compound TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL Source (TPIS_TRYBB) Sequence A:  SKPQPIAAANWKSLSELIDLFNSTSINHDVQCVVASTFVH LAMTKERLSHPKFVIAAQNAGNADALASLKDFGVNWIVLG HSERRWYYGETNEIVADKVAAAVASGFMVIACIGETLQER ESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVWAIGT GKVATPQQAQEAHALIRSWVSSKIGADVAGELRILYGGSV NGKNARTLYQQRDVNGFLAGLKPEFVDIIKATQ B:  SKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVVA STFVHLAMTKERLSHPKFVIAAQNAGNADALASLKDFGVN WIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIGE TLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPV WAIGTGKVATPQQAQEAHALIRSWVSSKIGADVAGELRIL YGGSVNGKNARTLYQQRDVNGFLAGLKPEFVDIIKATQ Description Functional site 1) chain B residue 11 type sequence N description BINDING SITE FOR RESIDUE RES B 1251 source : AC1 2) chain B residue 13 type sequence K description BINDING SITE FOR RESIDUE RES B 1251 source : AC1 3) chain B residue 95 type sequence H description BINDING SITE FOR RESIDUE RES B 1251 source : AC1 4) chain B residue 167 type sequence E description BINDING SITE FOR RESIDUE RES B 1251 source : AC1 5) chain B residue 211 type sequence G description BINDING SITE FOR RESIDUE RES B 1251 source : AC1 6) chain B residue 212 type sequence G description BINDING SITE FOR RESIDUE RES B 1251 source : AC1 7) chain B residue 213 type sequence S description BINDING SITE FOR RESIDUE RES B 1251 source : AC1 8) chain B residue 232 type sequence L description BINDING SITE FOR RESIDUE RES B 1251 source : AC1 9) chain B residue 233 type sequence A description BINDING SITE FOR RESIDUE RES B 1251 source : AC1 10) chain B residue 234 type sequence G description BINDING SITE FOR RESIDUE RES B 1251 source : AC1 11) chain B residue 239 type sequence K description BINDING SITE FOR RESIDUE RES B 1251 source : AC1 12) chain A residue 165-175 type prosite sequence AYEPVWAIGTG description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG source prosite : PS00171 13) chain A residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 14) chain A residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 15) chain B residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 16) chain B residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 17) chain A residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 18) chain B residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 19) chain A residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 20) chain B residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2

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