|
|
eF-site ID
|
2x1t-A |
|
PDB Code
|
2x1t |
|
Chain
|
A |
|
click to enlarge
|
|
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Title
|
Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase |
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Classification
|
ISOMERASE |
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Compound
|
TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL |
|
Source
|
(TPIS_TRYBB) |
|
|
Sequence
|
A: |
SKPQPIAAANWKSLSELIDLFNSTSINHDVQCVVASTFVH
LAMTKERLSHPKFVIAAQNAGNADALASLKDFGVNWIVLG
HSERRWYYGETNEIVADKVAAAVASGFMVIACIGETLQER
ESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVWAIGT
GKVATPQQAQEAHALIRSWVSSKIGADVAGELRILYGGSV
NGKNARTLYQQRDVNGFLAGLKPEFVDIIKATQ
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
165-175 |
| type |
prosite |
| sequence |
AYEPVWAIGTG
|
| description |
TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG
|
| source |
prosite : PS00171
|
|
|
2)
|
chain |
A |
| residue |
11 |
| type |
BINDING |
| sequence |
N
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
3)
|
chain |
A |
| residue |
13 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
A |
| residue |
95 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Electrophile
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
A |
| residue |
167 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
Proton acceptor
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|