eF-site ID 2x1s-B PDB Code 2x1s Chain B click to enlarge Title Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase Classification ISOMERASE Compound TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL Source Trypanosoma brucei brucei (TPIS_TRYBB) Sequence B:  SKPQPIAAANWKSSPDSLSELIDLFNSTSINHDVQCVVAS TFVHLAMTKERLSHPKFVIAAQNAGNADALASLKDFGVNW IVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIGET LQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVW AIGTGKVATPQQAQEAHALIRSWVSSKIGADVAGELRILY GGSVNGKNARTLYQQRDVNGFLAGLKPEFVDIIKATQ Description Functional site 1) chain B residue 32 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC3 2) chain B residue 34 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC3 3) chain B residue 35 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC3 4) chain B residue 247 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC3 5) chain B residue 250 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC3 6) chain B residue 11 type sequence N description BINDING SITE FOR RESIDUE X1S B 1252 source : AC4 7) chain B residue 95 type sequence H description BINDING SITE FOR RESIDUE X1S B 1252 source : AC4 8) chain B residue 167 type sequence E description BINDING SITE FOR RESIDUE X1S B 1252 source : AC4 9) chain B residue 171 type sequence A description BINDING SITE FOR RESIDUE X1S B 1252 source : AC4 10) chain B residue 172 type sequence I description BINDING SITE FOR RESIDUE X1S B 1252 source : AC4 11) chain B residue 173 type sequence G description BINDING SITE FOR RESIDUE X1S B 1252 source : AC4 12) chain B residue 212 type sequence G description BINDING SITE FOR RESIDUE X1S B 1252 source : AC4 13) chain B residue 213 type sequence S description BINDING SITE FOR RESIDUE X1S B 1252 source : AC4 14) chain B residue 232 type sequence L description BINDING SITE FOR RESIDUE X1S B 1252 source : AC4 15) chain B residue 234 type sequence G description BINDING SITE FOR RESIDUE X1S B 1252 source : AC4 16) chain B residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 17) chain B residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 18) chain B residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 19) chain B residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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