eF-site ID 2x1s-A PDB Code 2x1s Chain A click to enlarge Title Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase Classification ISOMERASE Compound TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL Source Trypanosoma brucei brucei (TPIS_TRYBB) Sequence A:  SKPQPIAAANSLSELIDLFNSTSINHDVQCVVASTFVHLA MTKERLSHPKFVIAAQNAGNADALASLKDFGVNWIVLGHS ERRWYYGETNEIVADKVAAAVASGFMVIACIGETLQERES GRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVWAIGTGK VATPQQAQEAHALIRSWVSSKIGADVAGELRILYGGSVNG KNARTLYQQRDVNGFLAGLKPEFVDIIKATQ Description Functional site 1) chain A residue 11 type sequence N description BINDING SITE FOR RESIDUE X1S A 1251 source : AC1 2) chain A residue 95 type sequence H description BINDING SITE FOR RESIDUE X1S A 1251 source : AC1 3) chain A residue 167 type sequence E description BINDING SITE FOR RESIDUE X1S A 1251 source : AC1 4) chain A residue 171 type sequence A description BINDING SITE FOR RESIDUE X1S A 1251 source : AC1 5) chain A residue 172 type sequence I description BINDING SITE FOR RESIDUE X1S A 1251 source : AC1 6) chain A residue 173 type sequence G description BINDING SITE FOR RESIDUE X1S A 1251 source : AC1 7) chain A residue 212 type sequence G description BINDING SITE FOR RESIDUE X1S A 1251 source : AC1 8) chain A residue 213 type sequence S description BINDING SITE FOR RESIDUE X1S A 1251 source : AC1 9) chain A residue 32 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1252 source : AC2 10) chain A residue 34 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1252 source : AC2 11) chain A residue 35 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1252 source : AC2 12) chain A residue 247 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1252 source : AC2 13) chain A residue 250 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1252 source : AC2 14) chain A residue 103 type ACT_SITE sequence G description Electrophile source Swiss-Prot : SWS_FT_FI1 15) chain A residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 16) chain A residue 175 type ACT_SITE sequence G description Proton acceptor source Swiss-Prot : SWS_FT_FI2 17) chain A residue 165-175 type prosite sequence AYEPVWAIGTG description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG source prosite : PS00171

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