eF-site ID 2x1r-AB PDB Code 2x1r Chain A, B click to enlarge Title Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase Classification ISOMERASE Compound TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL Source (TPIS_TRYBB) Sequence A:  SKPQPIAAANWSLSELIDLFNSTSINHDVQCVVASTFVHL AMTKERLSHPKFVIAAQNAGNADALASLKDFGVNWIVLGH SERRWYYGETNEIVADKVAAAVASGFMVIACIGETLQERE SGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVWAIGTG KVATPQQAQEAHALIRSWVSSKIGADVAGELRILYGGSVN GKNARTLYQQRDVNGFLAGLKPEFVDIIKATQ B:  SKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVVA STFVHLAMTKERLSHPKFVIAAQNAGNADALASLKDFGVN WIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIGE TLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPV WAIGTGKVATPQQAQEAHALIRSWVSSKIGADVAGELRIL YGGSVNGKNARTLYQQRDVNGFLAGLKPEFVDIIKATQ Description Functional site 1) chain A residue 32 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 2) chain A residue 34 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 3) chain A residue 35 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 4) chain A residue 247 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 5) chain A residue 250 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 6) chain A residue 11 type sequence N description BINDING SITE FOR RESIDUE X1R A 1252 source : AC2 7) chain A residue 95 type sequence H description BINDING SITE FOR RESIDUE X1R A 1252 source : AC2 8) chain A residue 167 type sequence E description BINDING SITE FOR RESIDUE X1R A 1252 source : AC2 9) chain A residue 171 type sequence A description BINDING SITE FOR RESIDUE X1R A 1252 source : AC2 10) chain A residue 172 type sequence I description BINDING SITE FOR RESIDUE X1R A 1252 source : AC2 11) chain A residue 173 type sequence G description BINDING SITE FOR RESIDUE X1R A 1252 source : AC2 12) chain A residue 212 type sequence G description BINDING SITE FOR RESIDUE X1R A 1252 source : AC2 13) chain A residue 213 type sequence S description BINDING SITE FOR RESIDUE X1R A 1252 source : AC2 14) chain B residue 32 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC3 15) chain B residue 33 type sequence I description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC3 16) chain B residue 34 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC3 17) chain B residue 35 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC3 18) chain B residue 247 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC3 19) chain B residue 250 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC3 20) chain B residue 31 type sequence T description BINDING SITE FOR RESIDUE SO4 B 1252 source : AC4 21) chain B residue 32 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1252 source : AC4 22) chain B residue 33 type sequence I description BINDING SITE FOR RESIDUE SO4 B 1252 source : AC4 23) chain B residue 57 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1252 source : AC4 24) chain B residue 59 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1252 source : AC4 25) chain B residue 95 type sequence H description BINDING SITE FOR RESIDUE X1R B 1253 source : AC5 26) chain B residue 167 type sequence E description BINDING SITE FOR RESIDUE X1R B 1253 source : AC5 27) chain B residue 171 type sequence A description BINDING SITE FOR RESIDUE X1R B 1253 source : AC5 28) chain B residue 172 type sequence I description BINDING SITE FOR RESIDUE X1R B 1253 source : AC5 29) chain B residue 173 type sequence G description BINDING SITE FOR RESIDUE X1R B 1253 source : AC5 30) chain B residue 212 type sequence G description BINDING SITE FOR RESIDUE X1R B 1253 source : AC5 31) chain B residue 213 type sequence S description BINDING SITE FOR RESIDUE X1R B 1253 source : AC5 32) chain B residue 232 type sequence L description BINDING SITE FOR RESIDUE X1R B 1253 source : AC5 33) chain B residue 234 type sequence G description BINDING SITE FOR RESIDUE X1R B 1253 source : AC5 34) chain B residue 239 type sequence K description BINDING SITE FOR RESIDUE X1R B 1253 source : AC5 35) chain A residue 165-175 type prosite sequence AYEPVWAIGTG description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG source prosite : PS00171 36) chain A residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 37) chain B residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 38) chain A residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 39) chain B residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 40) chain A residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 41) chain B residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 42) chain B residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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