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eF-site ID
|
2x10-A |
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PDB Code
|
2x10 |
|
Chain
|
A |
|
click to enlarge
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Title
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Crystal structure of the complete EphA2 ectodomain |
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Classification
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RECEPTOR |
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Compound
|
EPHRIN TYPE-A RECEPTOR 2 |
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Source
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(EPHA2_HUMAN) |
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Sequence
|
A: |
AKEVVLLDFAAALGWLTHPYGKGWDLXQNIXNDXPIYXYS
VCNVXSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSF
PGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPD
EITVSLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVY
YKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVP
PGGEEPRXHCAVDGEWLVPIGQCLCQAGYEKVEDACQACS
PGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAP
QDPASXPCTRPPSAPHYLTAVGXGAKVELRWTPPQDSGGR
EDIVYSVTCEQCGPCEASVRYSEPPHGLTRTSVTVSDLEP
HXNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRL
EGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNV
RRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEF
QTLSP
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
407 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
A |
| residue |
182-202 |
| type |
prosite |
| sequence |
FQDIGACVALLSVRVYYKKCP
|
| description |
RECEPTOR_TYR_KIN_V_1 Receptor tyrosine kinase class V signature 1. FqDiGACVALLSVRVyykKCP
|
| source |
prosite : PS00790
|
|
|
3)
|
chain |
A |
| residue |
247-267 |
| type |
prosite |
| sequence |
CAVDGEWLVPIGQCLCQAGYE
|
| description |
RECEPTOR_TYR_KIN_V_2 Receptor tyrosine kinase class V signature 2. CavDGEWlv.PIGqClCqaGYE
|
| source |
prosite : PS00791
|
|
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4)
|
chain |
A |
| residue |
260-273 |
| type |
prosite |
| sequence |
CLCQAGYEKVEDAC
|
| description |
EGF_2 EGF-like domain signature 2. ClCqaGYekveda..C
|
| source |
prosite : PS01186
|
|
|
5)
|
chain |
A |
| residue |
435 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
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