eF-site ID 2wxg-A
PDB Code 2wxg
Chain A

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Title The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW13.
Classification TRANSFERASE
Compound PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
Source (Q3UDT3_MOUSE)
Sequence A:  VKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCE
EAAAHRQQLGWVEWLQYSFPLQLEPNRALLVNVKFEGSEE
SFTFQVSTKDMPLALMACALRKKATVFRQPLEQPEEYALQ
VNGRHEYLYGNYPLCHFQYICSCLHSGLTPHLTMVHSSSI
LAMRDEQSNLWSLEQPFSIELIEGRKVNAMKLVVQAGLFH
GNEMLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMAR
LCFALYAVVDCPIAWANLMLFDYKDQLKTGERCLYMWPSV
ELLNPAGTVRGNPNTESAAALVIYLPEVAPVYFPALEKIL
ELEEELREILERSGELYEHEKDLVWKMRHEVQEHFPEALA
RLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSF
PDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDC
ELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLI
MEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTT
KPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVE
QCTFMDSKMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQD
MLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEV
VLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEA
LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQL
FHIDFGHFLGNFKNRERVPFILTYDFVHVIQQGKTNNSEK
FERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCS
KDIQYLKDSLALGKTEEEALKHFRVKFNEALRESW
Description


Functional site

1) chain A
residue 750
type
sequence T
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

2) chain A
residue 751
type
sequence F
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

3) chain A
residue 752
type
sequence M
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

4) chain A
residue 758
type
sequence P
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

5) chain A
residue 760
type
sequence W
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

6) chain A
residue 777
type
sequence I
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

7) chain A
residue 779
type
sequence K
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

8) chain A
residue 787
type
sequence D
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

9) chain A
residue 813
type
sequence Y
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

10) chain A
residue 825
type
sequence I
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

11) chain A
residue 826
type
sequence E
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

12) chain A
residue 828
type
sequence V
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

13) chain A
residue 832
type
sequence D
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

14) chain A
residue 833
type
sequence T
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

15) chain A
residue 900
type
sequence M
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

16) chain A
residue 910
type
sequence I
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

17) chain A
residue 911
type
sequence D
description BINDING SITE FOR RESIDUE ZZN A 1500
source : AC1

18) chain A
residue 778-792
type prosite
sequence FKNGDDLRQDMLTLQ
description PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ
source prosite : PS00915

19) chain A
residue 878-898
type prosite
sequence SCAGYCVATYVLGIGDRHSDN
description PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatYVLgIgDRHsdN
source prosite : PS00916

20) chain A
residue 524
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0000250|UniProtKB:O00329
source Swiss-Prot : SWS_FT_FI1


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