eF-site ID 2wxf-A PDB Code 2wxf Chain A click to enlarge Title The crystal structure of the murine class IA PI 3-kinase p110delta in complex with PIK-39. Classification TRANSFERASE Compound PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM Source (Q3UDT3_MOUSE) Sequence A:  VKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCE EAAAHRQQLGWVEWLQYSFPLQLEPNRALLVNVKFEGSEE SFTFQVSTKDMPLALMACALRKKATVFRQQPEEYALQVNG RHEYLYGNYPLCHFQYICSCLHSGLTPHLTMVHSSSILAM RDEQSNLWSLEQPFSIELIEGRKVNAMKLVVQAGLFHGNE MLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCF ALYAVVDCPIAWANLMLFDYKDQLKTGERCLYMWPSVLLN PAGTVRGNPNTESAAALVIYLPEVAPVYFPALEKILELLR EILERELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWN KHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFA IKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGR ALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGST HHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKEMMH MCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKM KPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQL MDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIAN IQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFT LSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFL GNFRVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYT ILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALG KTEEEALKHFRVKFNEALRESW Description Functional site 1) chain A residue 751 type sequence F description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 2) chain A residue 752 type sequence M description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 3) chain A residue 758 type sequence P description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 4) chain A residue 759 type sequence L description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 5) chain A residue 760 type sequence W description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 6) chain A residue 813 type sequence Y description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 7) chain A residue 825 type sequence I description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 8) chain A residue 826 type sequence E description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 9) chain A residue 828 type sequence V description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 10) chain A residue 831 type sequence S description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 11) chain A residue 832 type sequence D description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 12) chain A residue 833 type sequence T description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 13) chain A residue 836 type sequence N description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 14) chain A residue 900 type sequence M description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 15) chain A residue 910 type sequence I description BINDING SITE FOR RESIDUE 039 A 1500 source : AC1 16) chain A residue 524 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:O00329 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 778-792 type prosite sequence FKNGDDLRQDMLTLQ description PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ source prosite : PS00915 18) chain A residue 878-898 type prosite sequence SCAGYCVATYVLGIGDRHSDN description PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatYVLgIgDRHsdN source prosite : PS00916

Display surface Download Links