eF-site ID 2wx2-A
PDB Code 2wx2
Chain A

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Title X-RAY STRUCTURE OF CYP51 FROM THE HUMAN PATHOGEN TRYPANOSOMA CRUZI IN COMPLEX WITH FLUCONAZOLE
Classification OXIDOREDUCTASE
Compound LANOSTEROL 14-ALPHA-DEMETHYLASE
Source (Q7Z1V1_TRYCR)
Sequence A:  TTRPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKS
GVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTI
MTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPA
IQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFG
EDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPR
CREARAELQKILGEIIVAREKESDLLGGLLKAVYRDGTRM
SLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWL
DKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPL
LMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPN
PRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTIL
ATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRK
K
Description


Functional site

1) chain A
residue 103
type
sequence Y
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

2) chain A
residue 116
type
sequence Y
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

3) chain A
residue 127
type
sequence L
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

4) chain A
residue 134
type
sequence L
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

5) chain A
residue 288
type
sequence A
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

6) chain A
residue 291
type
sequence A
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

7) chain A
residue 292
type
sequence G
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

8) chain A
residue 295
type
sequence T
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

9) chain A
residue 296
type
sequence S
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

10) chain A
residue 299
type
sequence T
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

11) chain A
residue 356
type
sequence L
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

12) chain A
residue 359
type
sequence V
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

13) chain A
residue 361
type
sequence R
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

14) chain A
residue 414
type
sequence G
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

15) chain A
residue 415
type
sequence F
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

16) chain A
residue 416
type
sequence G
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

17) chain A
residue 420
type
sequence H
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

18) chain A
residue 422
type
sequence C
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

19) chain A
residue 423
type
sequence I
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

20) chain A
residue 428
type
sequence A
description BINDING SITE FOR RESIDUE HEM A 1450
source : AC1

21) chain A
residue 103
type
sequence Y
description BINDING SITE FOR RESIDUE TPF A 1460
source : AC2

22) chain A
residue 106
type
sequence M
description BINDING SITE FOR RESIDUE TPF A 1460
source : AC2

23) chain A
residue 116
type
sequence Y
description BINDING SITE FOR RESIDUE TPF A 1460
source : AC2

24) chain A
residue 287
type
sequence A
description BINDING SITE FOR RESIDUE TPF A 1460
source : AC2

25) chain A
residue 290
type
sequence F
description BINDING SITE FOR RESIDUE TPF A 1460
source : AC2

26) chain A
residue 291
type
sequence A
description BINDING SITE FOR RESIDUE TPF A 1460
source : AC2

27) chain A
residue 356
type
sequence L
description BINDING SITE FOR RESIDUE TPF A 1460
source : AC2

28) chain A
residue 415-424
type prosite
sequence FGAGVHKCIG
description CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGaGVHKCIG
source prosite : PS00086

29) chain A
residue 422
type BINDING
sequence C
description axial binding residue => ECO:0000250|UniProtKB:P0A512
source Swiss-Prot : SWS_FT_FI1


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