eF-site ID 2wuz-B PDB Code 2wuz Chain B click to enlarge Title X-ray structure of CYP51 from Trypanosoma cruzi in complex with fluconazole in alternative conformation Classification OXIDOREDUCTASE Compound LANOSTEROL 14-ALPHA-DEMETHYLASE, PUTATIVE Source (Q5I4E1_TRYCR) Sequence B:  RPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGV FTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMT PVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQ HEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGED LRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSA RCREARAELQKILGEIIVAREKEDLLGGLLKAVYRDGTRM SLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWL DKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPL LMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPN PRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTIL ATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRK KKLP Description Functional site 1) chain B residue 103 type sequence Y description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 2) chain B residue 116 type sequence Y description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 3) chain B residue 124 type sequence R description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 4) chain B residue 127 type sequence L description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 5) chain B residue 130 type sequence L description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 6) chain B residue 134 type sequence L description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 7) chain B residue 288 type sequence A description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 8) chain B residue 291 type sequence A description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 9) chain B residue 292 type sequence G description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 10) chain B residue 295 type sequence T description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 11) chain B residue 299 type sequence T description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 12) chain B residue 355 type sequence P description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 13) chain B residue 356 type sequence L description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 14) chain B residue 359 type sequence V description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 15) chain B residue 361 type sequence R description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 16) chain B residue 414 type sequence G description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 17) chain B residue 415 type sequence F description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 18) chain B residue 416 type sequence G description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 19) chain B residue 420 type sequence H description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 20) chain B residue 422 type sequence C description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 21) chain B residue 423 type sequence I description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 22) chain B residue 424 type sequence G description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 23) chain B residue 103 type sequence Y description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 24) chain B residue 106 type sequence M description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 25) chain B residue 110 type sequence F description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 26) chain B residue 287 type sequence A description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 27) chain B residue 291 type sequence A description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 28) chain B residue 295 type sequence T description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 29) chain B residue 356 type sequence L description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 30) chain B residue 460 type sequence M description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 31) chain B residue 461 type sequence V description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 32) chain B residue 422 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P0A512 source Swiss-Prot : SWS_FT_FI1

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