eF-site ID 2wuz-AB PDB Code 2wuz Chain A, B click to enlarge Title X-ray structure of CYP51 from Trypanosoma cruzi in complex with fluconazole in alternative conformation Classification OXIDOREDUCTASE Compound LANOSTEROL 14-ALPHA-DEMETHYLASE, PUTATIVE Source (Q5I4E1_TRYCR) Sequence A:  TRPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSG VFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIM TPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAI QHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGE DLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQS ARCREARAELQKILGEIIVAREKENTSDLLGGLLKAVYRD GTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKN KKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRR DPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEE AFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQV KTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVK YTRK B:  RPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGV FTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMT PVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQ HEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGED LRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSA RCREARAELQKILGEIIVAREKEDLLGGLLKAVYRDGTRM SLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWL DKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPL LMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPN PRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTIL ATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRK KKLP Description Functional site 1) chain A residue 103 type sequence Y description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 2) chain A residue 116 type sequence Y description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 3) chain A residue 124 type sequence R description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 4) chain A residue 127 type sequence L description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 5) chain A residue 288 type sequence A description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 6) chain A residue 291 type sequence A description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 7) chain A residue 292 type sequence G description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 8) chain A residue 295 type sequence T description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 9) chain A residue 299 type sequence T description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 10) chain A residue 355 type sequence P description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 11) chain A residue 356 type sequence L description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 12) chain A residue 359 type sequence V description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 13) chain A residue 361 type sequence R description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 14) chain A residue 414 type sequence G description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 15) chain A residue 415 type sequence F description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 16) chain A residue 416 type sequence G description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 17) chain A residue 419 type sequence V description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 18) chain A residue 420 type sequence H description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 19) chain A residue 422 type sequence C description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 20) chain A residue 423 type sequence I description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 21) chain A residue 424 type sequence G description BINDING SITE FOR RESIDUE HEM A 1450 source : AC1 22) chain A residue 103 type sequence Y description BINDING SITE FOR RESIDUE TPF A 1460 source : AC2 23) chain A residue 110 type sequence F description BINDING SITE FOR RESIDUE TPF A 1460 source : AC2 24) chain A residue 287 type sequence A description BINDING SITE FOR RESIDUE TPF A 1460 source : AC2 25) chain A residue 291 type sequence A description BINDING SITE FOR RESIDUE TPF A 1460 source : AC2 26) chain A residue 295 type sequence T description BINDING SITE FOR RESIDUE TPF A 1460 source : AC2 27) chain A residue 356 type sequence L description BINDING SITE FOR RESIDUE TPF A 1460 source : AC2 28) chain A residue 460 type sequence M description BINDING SITE FOR RESIDUE TPF A 1460 source : AC2 29) chain A residue 461 type sequence V description BINDING SITE FOR RESIDUE TPF A 1460 source : AC2 30) chain B residue 103 type sequence Y description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 31) chain B residue 116 type sequence Y description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 32) chain B residue 124 type sequence R description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 33) chain B residue 127 type sequence L description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 34) chain B residue 130 type sequence L description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 35) chain B residue 134 type sequence L description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 36) chain B residue 288 type sequence A description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 37) chain B residue 291 type sequence A description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 38) chain B residue 292 type sequence G description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 39) chain B residue 295 type sequence T description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 40) chain B residue 299 type sequence T description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 41) chain B residue 355 type sequence P description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 42) chain B residue 356 type sequence L description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 43) chain B residue 359 type sequence V description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 44) chain B residue 361 type sequence R description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 45) chain B residue 414 type sequence G description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 46) chain B residue 415 type sequence F description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 47) chain B residue 416 type sequence G description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 48) chain B residue 420 type sequence H description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 49) chain B residue 422 type sequence C description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 50) chain B residue 423 type sequence I description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 51) chain B residue 424 type sequence G description BINDING SITE FOR RESIDUE HEM B 1450 source : AC3 52) chain B residue 103 type sequence Y description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 53) chain B residue 106 type sequence M description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 54) chain B residue 110 type sequence F description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 55) chain B residue 287 type sequence A description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 56) chain B residue 291 type sequence A description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 57) chain B residue 295 type sequence T description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 58) chain B residue 356 type sequence L description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 59) chain B residue 460 type sequence M description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 60) chain B residue 461 type sequence V description BINDING SITE FOR RESIDUE TPF B 1460 source : AC4 61) chain A residue 415-424 type prosite sequence FGAGVHKCIG description CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGaGVHKCIG source prosite : PS00086 62) chain A residue 422 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P0A512 source Swiss-Prot : SWS_FT_FI1 63) chain B residue 422 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P0A512 source Swiss-Prot : SWS_FT_FI1

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