eF-site ID 2wsq-ABCD PDB Code 2wsq Chain A, B, C, D click to enlarge Title MonoTIM mutant RMM0-1, dimeric form. Classification ISOMERASE Compound TRIOSE PHOSPHATE ISOMERASE, GLYCOSOMAL Source (2WSQ) Sequence A:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV APSFVHLAMTKERLSHPKFVIAAQNAGNADGLASLKDFGV NWIVLGHSERRAYYGETNEIVADKVAAAVASGFMVIACIG ETLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEP VWAIGTGKVATPQQAQETHALIRSWVSSKIGADVAGELRI LYGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKA TQ B:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV APSFVHLAMTKERLSHPKFVIAAQNAGNADGLASLKDFGV NWIVLGHSERRAYYGETNEIVADKVAAAVASGFMVIACIG ETLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEP VWAIGTGKVATPQQAQETHALIRSWVSSKIGADVAGELRI LYGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKA TQ C:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV APSFVHLAMTKERLSHPKFVIAAQNAGNADGLASLKDFGV NWIVLGHSERRAYYGETNEIVADKVAAAVASGFMVIACIG ETLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEP VWAIGTGKVATPQQAQETHALIRSWVSSKIGADVAGELRI LYGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKA TQ D:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV APSFVHLAMTKERLSHPKFVIAAQNAGNADGLASLKDFGV NWIVLGHSERRAYYGETNEIVADKVAAAVASGFMVIACIG ETLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEP VWAIGTGKVATPQQAQETHALIRSWVSSKIGADVAGELRI LYGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKA TQ Description Functional site 1) chain A residue 172 type sequence I description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 2) chain A residue 173 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 3) chain A residue 213 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 4) chain A residue 234 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 5) chain A residue 235 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1251 source : AC1 6) chain B residue 171 type sequence A description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC2 7) chain B residue 173 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC2 8) chain B residue 212 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC2 9) chain B residue 213 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC2 10) chain B residue 234 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC2 11) chain B residue 235 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1251 source : AC2 12) chain C residue 171 type sequence A description BINDING SITE FOR RESIDUE SO4 C 1251 source : AC3 13) chain C residue 172 type sequence I description BINDING SITE FOR RESIDUE SO4 C 1251 source : AC3 14) chain C residue 173 type sequence G description BINDING SITE FOR RESIDUE SO4 C 1251 source : AC3 15) chain C residue 213 type sequence S description BINDING SITE FOR RESIDUE SO4 C 1251 source : AC3 16) chain C residue 234 type sequence G description BINDING SITE FOR RESIDUE SO4 C 1251 source : AC3 17) chain C residue 235 type sequence G description BINDING SITE FOR RESIDUE SO4 C 1251 source : AC3 18) chain D residue 171 type sequence A description BINDING SITE FOR RESIDUE SO4 D 1251 source : AC4 19) chain D residue 172 type sequence I description BINDING SITE FOR RESIDUE SO4 D 1251 source : AC4 20) chain D residue 173 type sequence G description BINDING SITE FOR RESIDUE SO4 D 1251 source : AC4 21) chain D residue 213 type sequence S description BINDING SITE FOR RESIDUE SO4 D 1251 source : AC4 22) chain D residue 234 type sequence G description BINDING SITE FOR RESIDUE SO4 D 1251 source : AC4 23) chain D residue 235 type sequence G description BINDING SITE FOR RESIDUE SO4 D 1251 source : AC4 24) chain A residue 226 type sequence R description BINDING SITE FOR RESIDUE SO4 C 1252 source : AC5 25) chain C residue 199 type sequence G description BINDING SITE FOR RESIDUE SO4 C 1252 source : AC5 26) chain C residue 200 type sequence A description BINDING SITE FOR RESIDUE SO4 C 1252 source : AC5 27) chain C residue 201 type sequence D description BINDING SITE FOR RESIDUE SO4 C 1252 source : AC5 28) chain B residue 152 type sequence K description BINDING SITE FOR RESIDUE SO4 D 1252 source : AC6 29) chain D residue 156 type sequence K description BINDING SITE FOR RESIDUE SO4 D 1252 source : AC6 30) chain D residue 199 type sequence G description BINDING SITE FOR RESIDUE SO4 D 1252 source : AC6 31) chain D residue 200 type sequence A description BINDING SITE FOR RESIDUE SO4 D 1252 source : AC6 32) chain D residue 201 type sequence D description BINDING SITE FOR RESIDUE SO4 D 1252 source : AC6 33) chain D residue 202 type sequence V description BINDING SITE FOR RESIDUE SO4 D 1252 source : AC6 34) chain B residue 160 type sequence A description BINDING SITE FOR RESIDUE SO4 B 1252 source : AC7 35) chain B residue 205 type sequence E description BINDING SITE FOR RESIDUE SO4 B 1252 source : AC7 36) chain B residue 207 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1252 source : AC7 37) chain B residue 98 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1253 source : AC8 38) chain B residue 102 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 1253 source : AC8 39) chain C residue 98 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1253 source : AC8 40) chain C residue 102 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 1253 source : AC8 41) chain A residue 165-175 type prosite sequence AYEPVWAIGTG description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG source prosite : PS00171 42) chain A residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 43) chain B residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 44) chain C residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 45) chain D residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 46) chain A residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 47) chain B residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 48) chain C residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 49) chain D residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 50) chain A residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 51) chain A residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 52) chain B residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 53) chain B residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 54) chain C residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 55) chain C residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 56) chain D residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 57) chain D residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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