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eF-site ID
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2wpa-B |
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PDB Code
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2wpa |
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Chain
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B |
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click to enlarge
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Title
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Optimisation of 6,6-Dimethyl Pyrrolo 3,4-c pyrazoles: Identification of PHA-793887, a Potent CDK Inhibitor Suitable for Intravenous Dosing |
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Classification
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CELL CYCLE |
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Compound
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CELL DIVISION PROTEIN KINASE 2 |
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Source
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(CCNA2_HUMAN) |
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Sequence
|
B: |
VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAIL
VDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ
LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRM
EHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAM
FLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYK
NSKYHGVSLLNPPETLNL
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Description
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(1) |
CELL DIVISION PROTEIN KINASE 2 (E.C.2.7.1.37), CYCLIN A2
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Functional site
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1)
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chain |
B |
| residue |
211-242 |
| type |
prosite |
| sequence |
RAILVDWLVEVGEEYKLQNETLHLAVNYIDRF
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| description |
CYCLINS Cyclins signature. RaiLvdWLvevgeeykLqnetLhlAVnYIDRF
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| source |
prosite : PS00292
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