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eF-site ID
|
2won-B |
|
PDB Code
|
2won |
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Chain
|
B |
|
click to enlarge
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Title
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Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (wild-type). |
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Classification
|
TRANSFERASE |
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Compound
|
HIV-1 REVERSE TRANSCRIPTASE |
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Source
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null (POL_HV1H2) |
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Sequence
|
B: |
SPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEME
KEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNK
RTQDFQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFR
KYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMT
KILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEEL
RQHLLRWGLTTPMGYELHPDKWTVQPIVLPEKDSWTVNDI
QKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTE
EAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQW
TYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITT
ESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFV
NTPPLVKLWYQLE
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Description
|
(1) |
HIV-1 REVERSE TRANSCRIPTASE (E.C.2.7.7.49)
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Functional site
|
|
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1)
|
chain |
B |
| residue |
401 |
| type |
SITE |
| sequence |
W
|
| description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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2)
|
chain |
B |
| residue |
414 |
| type |
SITE |
| sequence |
W
|
| description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
B |
| residue |
185 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
186 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
B |
| residue |
110 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|