eF-site ID 2won-AB PDB Code 2won Chain A, B click to enlarge Title Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (wild-type). Classification TRANSFERASE Compound HIV-1 REVERSE TRANSCRIPTASE Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2) Sequence A:  PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTE MEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIF QSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRT KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLC KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYD PSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETF YVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQ IIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRK B:  SPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEME KEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNK RTQDFQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFR KYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMT KILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEEL RQHLLRWGLTTPMGYELHPDKWTVQPIVLPEKDSWTVNDI QKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTE EAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQW TYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITT ESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFV NTPPLVKLWYQLE Description Functional site 1) chain A residue 95 type sequence P description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 2) chain A residue 100 type sequence L description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 3) chain A residue 101 type sequence K description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 4) chain A residue 102 type sequence K description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 5) chain A residue 103 type sequence K description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 6) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 7) chain A residue 179 type sequence V description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 8) chain A residue 188 type sequence Y description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 9) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 10) chain A residue 229 type sequence W description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 11) chain A residue 234 type sequence L description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 12) chain A residue 235 type sequence H description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 13) chain A residue 236 type sequence P description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 14) chain A residue 318 type sequence Y description BINDING SITE FOR RESIDUE ZZE A 1558 source : AC1 15) chain B residue 110 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 185 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 186 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 401 type SITE sequence W description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 414 type SITE sequence W description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 549 type SITE sequence D description Cleavage; by viral protease; partial => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 401 type SITE sequence W description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 22) chain A residue 414 type SITE sequence W description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 23) chain A residue 440 type SITE sequence F description Cleavage; by viral protease; partial => ECO:0000250 source Swiss-Prot : SWS_FT_FI5

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