eF-site ID 2won-AB
PDB Code 2won
Chain A, B

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Title Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (wild-type).
Classification TRANSFERASE
Compound HIV-1 REVERSE TRANSCRIPTASE
Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2)
Sequence A:  PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTE
MEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL
NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIF
QSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLC
KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYD
PSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET
WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETF
YVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQ
IIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRK
B:  SPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEME
KEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNK
RTQDFQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFR
KYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMT
KILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEEL
RQHLLRWGLTTPMGYELHPDKWTVQPIVLPEKDSWTVNDI
QKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTE
EAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQW
TYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITT
ESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFV
NTPPLVKLWYQLE
Description


Functional site

1) chain A
residue 95
type
sequence P
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

2) chain A
residue 100
type
sequence L
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

3) chain A
residue 101
type
sequence K
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

4) chain A
residue 102
type
sequence K
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

5) chain A
residue 103
type
sequence K
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

6) chain A
residue 106
type
sequence V
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

7) chain A
residue 179
type
sequence V
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

8) chain A
residue 188
type
sequence Y
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

9) chain A
residue 227
type
sequence F
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

10) chain A
residue 229
type
sequence W
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

11) chain A
residue 234
type
sequence L
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

12) chain A
residue 235
type
sequence H
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

13) chain A
residue 236
type
sequence P
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

14) chain A
residue 318
type
sequence Y
description BINDING SITE FOR RESIDUE ZZE A 1558
source : AC1

15) chain B
residue 110
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

16) chain B
residue 185
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

17) chain B
residue 186
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

18) chain B
residue 401
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

19) chain B
residue 414
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

20) chain A
residue 549
type SITE
sequence D
description Cleavage; by viral protease; partial => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

21) chain A
residue 401
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI4

22) chain A
residue 414
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI4

23) chain A
residue 440
type SITE
sequence F
description Cleavage; by viral protease; partial => ECO:0000250
source Swiss-Prot : SWS_FT_FI5


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