eF-site ID 2wog-ABC PDB Code 2wog Chain A, B, C click to enlarge Title Intermediate and final states of human kinesin Eg5 in complex with S-trityl-L-cysteine Classification CELL CYCLE Compound KINESIN-LIKE PROTEIN KIF11 Source (KIF11_HUMAN) Sequence A:  KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGG LADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMG YNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGII PRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSS DVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEK GAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELV KIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPY RESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLE YAHRAKNILNKPE B:  NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGL ADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGY NCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP RTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD VSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG AAKRTTAATLMNAYSSRSHSVFSVTIHMKEGEELVKIGKL NLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKL TRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRA KNILNKPE C:  KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGG LADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMG YNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGII PRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSS DVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEK GAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELV KIGKLNLVDLAGSENNQSLLTLGRVITALVERTPHVPYRE SKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYA HRAKNILNKP Description Functional site 1) chain A residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP A 600 source : AC1 2) chain A residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP A 600 source : AC1 3) chain A residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP A 600 source : AC1 4) chain A residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP A 600 source : AC1 5) chain A residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP A 600 source : AC1 6) chain A residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP A 600 source : AC1 7) chain A residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP A 600 source : AC1 8) chain A residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP A 600 source : AC1 9) chain A residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP A 600 source : AC1 10) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP A 600 source : AC1 11) chain A residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP A 600 source : AC1 12) chain A residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP A 600 source : AC1 13) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE MG A 601 source : AC2 14) chain B residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP B 600 source : AC3 15) chain B residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP B 600 source : AC3 16) chain B residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP B 600 source : AC3 17) chain B residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP B 600 source : AC3 18) chain B residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP B 600 source : AC3 19) chain B residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP B 600 source : AC3 20) chain B residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP B 600 source : AC3 21) chain B residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP B 600 source : AC3 22) chain B residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP B 600 source : AC3 23) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP B 600 source : AC3 24) chain B residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP B 600 source : AC3 25) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP B 600 source : AC3 26) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE MG B 601 source : AC4 27) chain C residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP C 600 source : AC5 28) chain C residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP C 600 source : AC5 29) chain C residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP C 600 source : AC5 30) chain C residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP C 600 source : AC5 31) chain C residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP C 600 source : AC5 32) chain C residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP C 600 source : AC5 33) chain C residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP C 600 source : AC5 34) chain C residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP C 600 source : AC5 35) chain C residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP C 600 source : AC5 36) chain C residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP C 600 source : AC5 37) chain C residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP C 600 source : AC5 38) chain C residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP C 600 source : AC5 39) chain C residue 112 type sequence T description BINDING SITE FOR RESIDUE MG C 601 source : AC6 40) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE ZZD A 1365 source : AC7 41) chain A residue 116 type sequence E description BINDING SITE FOR RESIDUE ZZD A 1365 source : AC7 42) chain A residue 117 type sequence G description BINDING SITE FOR RESIDUE ZZD A 1365 source : AC7 43) chain A residue 118 type sequence E description BINDING SITE FOR RESIDUE ZZD A 1365 source : AC7 44) chain A residue 119 type sequence R description BINDING SITE FOR RESIDUE ZZD A 1365 source : AC7 45) chain A residue 133 type sequence A description BINDING SITE FOR RESIDUE ZZD A 1365 source : AC7 46) chain A residue 137 type sequence P description BINDING SITE FOR RESIDUE ZZD A 1365 source : AC7 47) chain A residue 211 type sequence Y description BINDING SITE FOR RESIDUE ZZD A 1365 source : AC7 48) chain A residue 214 type sequence L description BINDING SITE FOR RESIDUE ZZD A 1365 source : AC7 49) chain A residue 215 type sequence E description BINDING SITE FOR RESIDUE ZZD A 1365 source : AC7 50) chain A residue 221 type sequence R description BINDING SITE FOR RESIDUE ZZD A 1365 source : AC7 51) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE ZZD B 1365 source : AC8 52) chain B residue 116 type sequence E description BINDING SITE FOR RESIDUE ZZD B 1365 source : AC8 53) chain B residue 117 type sequence G description BINDING SITE FOR RESIDUE ZZD B 1365 source : AC8 54) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE ZZD B 1365 source : AC8 55) chain B residue 119 type sequence R description BINDING SITE FOR RESIDUE ZZD B 1365 source : AC8 56) chain B residue 127 type sequence W description BINDING SITE FOR RESIDUE ZZD B 1365 source : AC8 57) chain B residue 137 type sequence P description BINDING SITE FOR RESIDUE ZZD B 1365 source : AC8 58) chain B residue 211 type sequence Y description BINDING SITE FOR RESIDUE ZZD B 1365 source : AC8 59) chain B residue 214 type sequence L description BINDING SITE FOR RESIDUE ZZD B 1365 source : AC8 60) chain B residue 215 type sequence E description BINDING SITE FOR RESIDUE ZZD B 1365 source : AC8 61) chain B residue 221 type sequence R description BINDING SITE FOR RESIDUE ZZD B 1365 source : AC8 62) chain C residue 112 type sequence T description BINDING SITE FOR RESIDUE ZZD C 1364 source : AC9 63) chain C residue 116 type sequence E description BINDING SITE FOR RESIDUE ZZD C 1364 source : AC9 64) chain C residue 117 type sequence G description BINDING SITE FOR RESIDUE ZZD C 1364 source : AC9 65) chain C residue 118 type sequence E description BINDING SITE FOR RESIDUE ZZD C 1364 source : AC9 66) chain C residue 137 type sequence P description BINDING SITE FOR RESIDUE ZZD C 1364 source : AC9 67) chain C residue 211 type sequence Y description BINDING SITE FOR RESIDUE ZZD C 1364 source : AC9 68) chain C residue 214 type sequence L description BINDING SITE FOR RESIDUE ZZD C 1364 source : AC9 69) chain C residue 221 type sequence R description BINDING SITE FOR RESIDUE ZZD C 1364 source : AC9 70) chain A residue 259-270 type prosite sequence GKLNLVDLAGSE description KINESIN_MOTOR_1 Kinesin motor domain signature. GKLnLVDLAGSE source prosite : PS00411 71) chain A residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 72) chain B residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 73) chain C residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 74) chain A residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 75) chain B residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 76) chain C residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2

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