eF-site ID 2wmz-ABC PDB Code 2wmz Chain A, B, C click to enlarge Title Structure of a mutated TolC Classification MEMBRANE PROTEIN Compound OUTER MEMBRANE PROTEIN TOLC Source Escherichia coli (strain K12) (TOLC_ECOLI) Sequence A:  ENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLP QLGLGADYTYSNGYRDANGINSNATSASLQLTQSIFDMSK WRALTLQEKAAGIQDVTYQTDQQTLILNTATAYFNVLNAI DVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDVQNARAQ YDTVLANELTARNNLDNAVEQLRQITGNYYPELAALNVEN FKTDKPQPVNALLKEAEKRNLSLLQARLSQDLAREQIRQA QDGHLPTLDLTASTGISDTSYSGSKTRGAAGTQYDDSNMG QNKVGLSFSLPIYQGGMVNSQVKQAQYNFVGASEQLESAH RSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEA GYSVGTSTIVDVLDATTTLYNAKQELANARYNYLINQLNI KSALGTLNEQDLLALNNALSKPVSTNPE B:  ENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLP QLGLGADYTYSNGYRDANGINSNATSASLQLTQSIFDMSK WRALTLQEKAAGIQDVTYQTDQQTLILNTATAYFNVLNAI DVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDVQNARAQ YDTVLANELTARNNLDNAVEQLRQITGNYYPELAALNVEN FKTDKPQPVNALLKEAEKRNLSLLQARLSQDLAREQIRQA QDGHLPTLDLTASTGISDTSYSGSKTRGAAGTQYDDSNMG QNKVGLSFSLPIYQGGMVNSQVKQAQYNFVGASEQLESAH RSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEA GYSVGTSTIVDVLDATTTLYNAKQELANARYNYLINQLNI KSALGTLNEQDLLALNNALSKPVSTNPE C:  ENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLP QLGLGADYTYSNGYRDANGINSNATSASLQLTQSIFDMSK WRALTLQEKAAGIQDVTYQTDQQTLILNTATAYFNVLNAI DVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDVQNARAQ YDTVLANELTARNNLDNAVEQLRQITGNYYPELAALNVEN FKTDKPQPVNALLKEAEKRNLSLLQARLSQDLAREQIRQA QDGHLPTLDLTASTGISDTSYSGSKTRGAAGTQYDDSNMG QNKVGLSFSLPIYQGGMVNSQVKQAQYNFVGASEQLESAH RSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEA GYSVGTSTIVDVLDATTTLYNAKQELANARYNYLINQLNI KSALGTLNEQDLLALNNALSKPVSTNPE Description Functional site 1) chain A residue 294 type sequence Q description BINDING SITE FOR RESIDUE CL A 1429 source : AC1 2) chain A residue 296 type sequence G description BINDING SITE FOR RESIDUE CL A 1429 source : AC1 3) chain A residue 297 type sequence M description BINDING SITE FOR RESIDUE CL A 1429 source : AC1 4) chain A residue 298 type sequence V description BINDING SITE FOR RESIDUE CL A 1429 source : AC1 5) chain A residue 42 type sequence L description BINDING SITE FOR RESIDUE PGE A 1430 source : AC2 6) chain A residue 43 type sequence G description BINDING SITE FOR RESIDUE PGE A 1430 source : AC2 7) chain B residue 294 type sequence Q description BINDING SITE FOR RESIDUE CL B 1429 source : AC3 8) chain B residue 296 type sequence G description BINDING SITE FOR RESIDUE CL B 1429 source : AC3 9) chain B residue 297 type sequence M description BINDING SITE FOR RESIDUE CL B 1429 source : AC3 10) chain B residue 298 type sequence V description BINDING SITE FOR RESIDUE CL B 1429 source : AC3 11) chain B residue 180 type sequence E description BINDING SITE FOR RESIDUE NA B 1430 source : AC4 12) chain C residue 332 type sequence N description BINDING SITE FOR RESIDUE NA B 1430 source : AC4 13) chain B residue 42 type sequence L description BINDING SITE FOR RESIDUE PGE B 1431 source : AC5 14) chain B residue 43 type sequence G description BINDING SITE FOR RESIDUE PGE B 1431 source : AC5 15) chain B residue 236 type sequence Q description BINDING SITE FOR RESIDUE PGE B 1432 source : AC6 16) chain B residue 301 type sequence Q description BINDING SITE FOR RESIDUE PGE B 1432 source : AC6 17) chain B residue 308 type sequence N description BINDING SITE FOR RESIDUE PGE B 1432 source : AC6 18) chain C residue 294 type sequence Q description BINDING SITE FOR RESIDUE CL C 1429 source : AC7 19) chain C residue 296 type sequence G description BINDING SITE FOR RESIDUE CL C 1429 source : AC7 20) chain C residue 297 type sequence M description BINDING SITE FOR RESIDUE CL C 1429 source : AC7 21) chain C residue 298 type sequence V description BINDING SITE FOR RESIDUE CL C 1429 source : AC7 22) chain C residue 236 type sequence Q description BINDING SITE FOR RESIDUE PGE C 1430 source : AC8 23) chain C residue 305 type sequence A description BINDING SITE FOR RESIDUE PGE C 1430 source : AC8 24) chain C residue 308 type sequence N description BINDING SITE FOR RESIDUE PGE C 1430 source : AC8 25) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE PGE C 1431 source : AC9 26) chain C residue 43 type sequence G description BINDING SITE FOR RESIDUE PGE C 1431 source : AC9 27) chain A residue 1-40 type TOPO_DOM sequence ENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLP description Periplasmic source Swiss-Prot : SWS_FT_FI1 28) chain A residue 75-246 type TOPO_DOM sequence IFDMSKWRALTLQEKAAGIQDVTYQTDQQTLILNTATAYF NVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDV QNARAQYDTVLANELTARNNLDNAVEQLRQITGNYYPELA ALNVENFKTDKPQPVNALLKEAEKRNLSLLQARLSQDLAR EQIRQAQDGHLP description Periplasmic source Swiss-Prot : SWS_FT_FI1 29) chain B residue 1-40 type TOPO_DOM sequence ENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLP description Periplasmic source Swiss-Prot : SWS_FT_FI1 30) chain B residue 75-246 type TOPO_DOM sequence IFDMSKWRALTLQEKAAGIQDVTYQTDQQTLILNTATAYF NVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDV QNARAQYDTVLANELTARNNLDNAVEQLRQITGNYYPELA ALNVENFKTDKPQPVNALLKEAEKRNLSLLQARLSQDLAR EQIRQAQDGHLP description Periplasmic source Swiss-Prot : SWS_FT_FI1 31) chain C residue 1-40 type TOPO_DOM sequence ENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLP description Periplasmic source Swiss-Prot : SWS_FT_FI1 32) chain C residue 75-246 type TOPO_DOM sequence IFDMSKWRALTLQEKAAGIQDVTYQTDQQTLILNTATAYF NVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDV QNARAQYDTVLANELTARNNLDNAVEQLRQITGNYYPELA ALNVENFKTDKPQPVNALLKEAEKRNLSLLQARLSQDLAR EQIRQAQDGHLP description Periplasmic source Swiss-Prot : SWS_FT_FI1 33) chain A residue 41-52 type TRANSMEM sequence QLGLGADYTYSN description Beta stranded; Name=S1 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 41-52 type TRANSMEM sequence QLGLGADYTYSN description Beta stranded; Name=S1 source Swiss-Prot : SWS_FT_FI2 35) chain C residue 41-52 type TRANSMEM sequence QLGLGADYTYSN description Beta stranded; Name=S1 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 53-60 type TOPO_DOM sequence GYRDANGI description Extracellular source Swiss-Prot : SWS_FT_FI3 37) chain A residue 258-278 type TOPO_DOM sequence DTSYSGSKTRGAAGTQYDDSN description Extracellular source Swiss-Prot : SWS_FT_FI3 38) chain B residue 53-60 type TOPO_DOM sequence GYRDANGI description Extracellular source Swiss-Prot : SWS_FT_FI3 39) chain B residue 258-278 type TOPO_DOM sequence DTSYSGSKTRGAAGTQYDDSN description Extracellular source Swiss-Prot : SWS_FT_FI3 40) chain C residue 53-60 type TOPO_DOM sequence GYRDANGI description Extracellular source Swiss-Prot : SWS_FT_FI3 41) chain C residue 258-278 type TOPO_DOM sequence DTSYSGSKTRGAAGTQYDDSN description Extracellular source Swiss-Prot : SWS_FT_FI3 42) chain A residue 61-74 type TRANSMEM sequence NSNATSASLQLTQS description Beta stranded; Name=S2 source Swiss-Prot : SWS_FT_FI4 43) chain B residue 61-74 type TRANSMEM sequence NSNATSASLQLTQS description Beta stranded; Name=S2 source Swiss-Prot : SWS_FT_FI4 44) chain C residue 61-74 type TRANSMEM sequence NSNATSASLQLTQS description Beta stranded; Name=S2 source Swiss-Prot : SWS_FT_FI4 45) chain A residue 247-257 type TRANSMEM sequence TLDLTASTGIS description Beta stranded; Name=S4 source Swiss-Prot : SWS_FT_FI5 46) chain B residue 247-257 type TRANSMEM sequence TLDLTASTGIS description Beta stranded; Name=S4 source Swiss-Prot : SWS_FT_FI5 47) chain C residue 247-257 type TRANSMEM sequence TLDLTASTGIS description Beta stranded; Name=S4 source Swiss-Prot : SWS_FT_FI5 48) chain A residue 279-289 type TRANSMEM sequence MGQNKVGLSFS description Beta stranded; Name=S5 source Swiss-Prot : SWS_FT_FI6 49) chain B residue 279-289 type TRANSMEM sequence MGQNKVGLSFS description Beta stranded; Name=S5 source Swiss-Prot : SWS_FT_FI6 50) chain C residue 279-289 type TRANSMEM sequence MGQNKVGLSFS description Beta stranded; Name=S5 source Swiss-Prot : SWS_FT_FI6

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