eF-site ID 2wmu-A
PDB Code 2wmu
Chain A

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Title Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
Classification TRANSFERASE
Compound SERINE/THREONINE-PROTEIN KINASE CHK1
Source Homo sapiens (Human) (CHK1_HUMAN)
Sequence A:  WDLVQTLGEVQLAVNRVTEEAVAVKIVDNIKKEICINKML
NHENVVKFYGHRREIQYLFLEYCSGGELFDRIEPDIGMPE
PDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL
KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREF
HAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEK
KTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRW
YNKPLK
Description


Functional site

1) chain A
residue 15
type
sequence L
description BINDING SITE FOR RESIDUE ZYU A 1271
source : AC1

2) chain A
residue 16
type
sequence G
description BINDING SITE FOR RESIDUE ZYU A 1271
source : AC1

3) chain A
residue 36
type
sequence A
description BINDING SITE FOR RESIDUE ZYU A 1271
source : AC1

4) chain A
residue 85
type
sequence E
description BINDING SITE FOR RESIDUE ZYU A 1271
source : AC1

5) chain A
residue 87
type
sequence C
description BINDING SITE FOR RESIDUE ZYU A 1271
source : AC1

6) chain A
residue 137
type
sequence L
description BINDING SITE FOR RESIDUE ZYU A 1271
source : AC1

7) chain A
residue 132
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:32357935
source Swiss-Prot : SWS_FT_FI5

8) chain A
residue 15-38
type prosite
sequence LGEVQLAVNRVTEEAVAVK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAYGEVQlAvnrvteea..........VAVK
source prosite : PS00107

9) chain A
residue 126-138
type prosite
sequence ITHRDIKPENLLL
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ItHrDIKpeNLLL
source prosite : PS00108

10) chain A
residue 130
type ACT_SITE
sequence D
description Proton acceptor
source Swiss-Prot : SWS_FT_FI1

11) chain A
residue 15
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 38
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2


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