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eF-site ID
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2win-J |
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PDB Code
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2win |
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Chain
|
J |
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click to enlarge
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Title
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C3 convertase (C3bBb) stabilized by SCIN |
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Classification
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IMMUNE SYSTEM |
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Compound
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COMPLEMENT C3 BETA CHAIN |
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Source
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ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; |
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Sequence
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J: |
KIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEK
VASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQL
NEINYEDHKLKSGTNTKKALQAVYSMMSWPDDVPPEGWNR
TRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPR
EDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDME
NLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKI
SVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKV
SVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVAL
IKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQK
EELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERD
AQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDS
GGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHAR
DFHINLFQVLPWLKEKLQDEDLGFLAA
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Description
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Functional site
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1)
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chain |
J |
| residue |
501 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
J |
| residue |
551 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
|
chain |
J |
| residue |
674 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
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|
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4)
|
chain |
J |
| residue |
260 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6546754
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| source |
Swiss-Prot : SWS_FT_FI2
|
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5)
|
chain |
J |
| residue |
266 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:2006911
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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6)
|
chain |
J |
| residue |
353 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754
|
| source |
Swiss-Prot : SWS_FT_FI4
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