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eF-site ID
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2win-F |
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PDB Code
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2win |
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Chain
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F |
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click to enlarge
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Title
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C3 convertase (C3bBb) stabilized by SCIN |
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Classification
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IMMUNE SYSTEM |
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Compound
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COMPLEMENT C3 BETA CHAIN |
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Source
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ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; |
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Sequence
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F: |
LDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKL
MNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFF
IDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNP
AFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEV
EVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPE
RLGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQM
TEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDE
TEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSAFVKRAP
STWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKP
DGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEA
KDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGY
ALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATS
YALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFM
VFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWE
SASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKD
QLTCNKFDLKVTIKPAPKNTMILEICTRYRGDQDATMSIL
DISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNT
LIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYY
NLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQKS
DDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYIM
AIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYL
MWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEENQ
KQCQDLGAFTESMVVFGCPN
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Description
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Functional site
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1)
|
chain |
F |
| residue |
1595 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952
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| source |
Swiss-Prot : SWS_FT_FI6
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2)
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chain |
F |
| residue |
988 |
| type |
CROSSLNK |
| sequence |
C
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| description |
Isoglutamyl cysteine thioester (Cys-Gln)
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| source |
Swiss-Prot : SWS_FT_FI7
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3)
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chain |
F |
| residue |
991 |
| type |
CROSSLNK |
| sequence |
Q
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| description |
Isoglutamyl cysteine thioester (Cys-Gln)
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| source |
Swiss-Prot : SWS_FT_FI7
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4)
|
chain |
F |
| residue |
917 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150
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| source |
Swiss-Prot : SWS_FT_FI5
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5)
|
chain |
F |
| residue |
1281 |
| type |
CARBOHYD |
| sequence |
R
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6546754
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| source |
Swiss-Prot : SWS_FT_FI2
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6)
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chain |
F |
| residue |
1298 |
| type |
CARBOHYD |
| sequence |
R
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6546754
|
| source |
Swiss-Prot : SWS_FT_FI2
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|
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7)
|
chain |
F |
| residue |
946 |
| type |
CARBOHYD |
| sequence |
S
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754
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| source |
Swiss-Prot : SWS_FT_FI4
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8)
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chain |
F |
| residue |
1299 |
| type |
CARBOHYD |
| sequence |
S
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754
|
| source |
Swiss-Prot : SWS_FT_FI4
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|
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9)
|
chain |
F |
| residue |
1551 |
| type |
CARBOHYD |
| sequence |
S
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754
|
| source |
Swiss-Prot : SWS_FT_FI4
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