eF-site/Summary 2wii-B

eF-site ID	2wii-B
PDB Code	2wii
Chain	B

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Title	Complement C3b in complex with factor H domains 1-4
Classification	IMMUNE SYSTEM
Compound	COMPLEMENT C3 BETA CHAIN
Source	ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS;

Sequence	B:	DEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLM NIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFI DLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPA FCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVE VKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPER LGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMT EDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDET EQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVK RAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEK QKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISL QEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAI AGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVE ATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQA TFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRI HWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAK AKDQLTCNKFDLKVTIKPAPKNTMILEICTRYRGDQDATM SILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSD RNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVY AYYNLEESCTRFYHPEKECRDELCRCAEENCFIQKSDDKV TLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYIMAIEQ TIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGL SSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEENQKQCQ DLGAFTESMVVFGCPN

Description

Functional site


1)	chain	B
	residue	1595
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16335952
	source	Swiss-Prot : SWS_FT_FI6

2)	chain	B
	residue	988
	type	CROSSLNK
	sequence	C
	description	Isoglutamyl cysteine thioester (Cys-Gln)
	source	Swiss-Prot : SWS_FT_FI7

3)	chain	B
	residue	991
	type	CROSSLNK
	sequence	Q
	description	Isoglutamyl cysteine thioester (Cys-Gln)
	source	Swiss-Prot : SWS_FT_FI7

4)	chain	B
	residue	917
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:14760718, ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:17051150
	source	Swiss-Prot : SWS_FT_FI5

5)	chain	B
	residue	985-993
	type	prosite
	sequence	PSGCGEQNM
	description	ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEQnM
	source	prosite : PS00477

6)	chain	B
	residue	1281
	type	SITE
	sequence	R
	description	Cleavage; by factor I
	source	Swiss-Prot : SWS_FT_FI2

7)	chain	B
	residue	1298
	type	SITE
	sequence	R
	description	Cleavage; by factor I
	source	Swiss-Prot : SWS_FT_FI2

8)	chain	B
	residue	1641
	type	SITE
	sequence	N
	description	Coordinates Mg2+ for interaction with Complement factor B Bb fragment => ECO:0000269\|PubMed:28264884, ECO:0000269\|PubMed:31507604
	source	Swiss-Prot : SWS_FT_FI3

9)	chain	B
	residue	946
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by FAM20C => ECO:0000269\|PubMed:26091039
	source	Swiss-Prot : SWS_FT_FI4

10)	chain	B
	residue	1299
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by FAM20C => ECO:0000269\|PubMed:26091039
	source	Swiss-Prot : SWS_FT_FI4

11)	chain	B
	residue	1551
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by FAM20C => ECO:0000269\|PubMed:26091039
	source	Swiss-Prot : SWS_FT_FI4