eF-site ID 2wi4-A
PDB Code 2wi4
Chain A

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Title Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
Classification CHAPERONE
Compound HEAT SHOCK PROTEIN, HSP 90-ALPHA
Source Homo sapiens (Human) (HS90A_HUMAN)
Sequence A:  EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDA
LDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFG
VGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTD
TGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIG
YPITLFVEK
Description


Functional site

1) chain A
residue 51
type
sequence N
description BINDING SITE FOR RESIDUE ZZ4 A 1224
source : AC1

2) chain A
residue 52
type
sequence S
description BINDING SITE FOR RESIDUE ZZ4 A 1224
source : AC1

3) chain A
residue 55
type
sequence A
description BINDING SITE FOR RESIDUE ZZ4 A 1224
source : AC1

4) chain A
residue 61
type
sequence Y
description BINDING SITE FOR RESIDUE ZZ4 A 1224
source : AC1

5) chain A
residue 93
type
sequence D
description BINDING SITE FOR RESIDUE ZZ4 A 1224
source : AC1

6) chain A
residue 98
type
sequence M
description BINDING SITE FOR RESIDUE ZZ4 A 1224
source : AC1

7) chain A
residue 102
type
sequence D
description BINDING SITE FOR RESIDUE ZZ4 A 1224
source : AC1

8) chain A
residue 107
type
sequence L
description BINDING SITE FOR RESIDUE ZZ4 A 1224
source : AC1

9) chain A
residue 138
type
sequence F
description BINDING SITE FOR RESIDUE ZZ4 A 1224
source : AC1

10) chain A
residue 184
type
sequence T
description BINDING SITE FOR RESIDUE ZZ4 A 1224
source : AC1

11) chain A
residue 51
type BINDING
sequence N
description
source Swiss-Prot : SWS_FT_FI1

12) chain A
residue 93
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI1

13) chain A
residue 138
type BINDING
sequence F
description
source Swiss-Prot : SWS_FT_FI1

14) chain A
residue 112
type BINDING
sequence K
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

15) chain A
residue 58
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000250|UniProtKB:P07901
source Swiss-Prot : SWS_FT_FI4

16) chain A
residue 84
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000250|UniProtKB:P07901
source Swiss-Prot : SWS_FT_FI4

17) chain A
residue 38-47
type prosite
sequence YSNKEIFLRE
description HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE
source prosite : PS00298


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