eF-site ID 2wi3-A PDB Code 2wi3 Chain A click to enlarge Title Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone Classification CHAPERONE Compound HEAT SHOCK PROTEIN, HSP 90-ALPHA Source Homo sapiens (Human) (HS90A_HUMAN) Sequence A:  EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDA LDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTG IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFG VGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTD TGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIG YPITLFVEK Description Functional site 1) chain A residue 110 type sequence I description BINDING SITE FOR RESIDUE MG A 1224 source : AC1 2) chain A residue 113 type sequence S description BINDING SITE FOR RESIDUE MG A 1224 source : AC1 3) chain A residue 48 type sequence L description BINDING SITE FOR RESIDUE ZZ3 A 1225 source : AC2 4) chain A residue 51 type sequence N description BINDING SITE FOR RESIDUE ZZ3 A 1225 source : AC2 5) chain A residue 55 type sequence A description BINDING SITE FOR RESIDUE ZZ3 A 1225 source : AC2 6) chain A residue 93 type sequence D description BINDING SITE FOR RESIDUE ZZ3 A 1225 source : AC2 7) chain A residue 107 type sequence L description BINDING SITE FOR RESIDUE ZZ3 A 1225 source : AC2 8) chain A residue 109 type sequence T description BINDING SITE FOR RESIDUE ZZ3 A 1225 source : AC2 9) chain A residue 184 type sequence T description BINDING SITE FOR RESIDUE ZZ3 A 1225 source : AC2 10) chain A residue 186 type sequence V description BINDING SITE FOR RESIDUE ZZ3 A 1225 source : AC2 11) chain A residue 38-47 type prosite sequence YSNKEIFLRE description HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE source prosite : PS00298

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