eF-site ID 2wi2-A PDB Code 2wi2 Chain A click to enlarge Title Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone Classification CHAPERONE Compound HEAT SHOCK PROTEIN HSP 90-ALPHA Source Homo sapiens (Human) (HS90A_HUMAN) Sequence A:  EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDA LDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTG IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFG VGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTD TGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIG YPITLFVEK Description Functional site 1) chain A residue 54 type sequence D description BINDING SITE FOR RESIDUE DMS A 1225 source : AC1 2) chain A residue 55 type sequence A description BINDING SITE FOR RESIDUE ZZ3 A 1226 source : AC2 3) chain A residue 93 type sequence D description BINDING SITE FOR RESIDUE ZZ3 A 1226 source : AC2 4) chain A residue 96 type sequence I description BINDING SITE FOR RESIDUE ZZ3 A 1226 source : AC2 5) chain A residue 184 type sequence T description BINDING SITE FOR RESIDUE ZZ3 A 1226 source : AC2 6) chain A residue 138 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI1 7) chain A residue 51 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 8) chain A residue 93 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 9) chain A residue 112 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 58 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P07901 source Swiss-Prot : SWS_FT_FI4 11) chain A residue 84 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P07901 source Swiss-Prot : SWS_FT_FI4 12) chain A residue 38-47 type prosite sequence YSNKEIFLRE description HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE source prosite : PS00298

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