eF-site ID 2wh5-ABCDEF PDB Code 2wh5 Chain A, B, C, D, E, F click to enlarge Title Crystal structure of human acyl-CoA binding domain 4 complexed with stearoyl-CoA Classification LIPID BINDING PROTEIN Compound ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4 Source Homo sapiens (Human) (ACBD4_HUMAN) Sequence A:  QKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMG PCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEM KLVAQKVIDT B:  QKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMG PCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEM KLVAQKVID C:  QKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMG PCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEM KLVAQKVIDT D:  QKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMG PCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEM KLVAQKVID E:  QKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMG PCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEM KLVAQKVID F:  QKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMG PCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEM KLVAQKVID Description Functional site 1) chain A residue 19 type sequence I description BINDING SITE FOR RESIDUE STE A 801 source : AC1 2) chain A residue 30 type sequence P description BINDING SITE FOR RESIDUE STE A 801 source : AC1 3) chain A residue 32 type sequence Y description BINDING SITE FOR RESIDUE STE A 801 source : AC1 4) chain A residue 16 type sequence V description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 5) chain A residue 19 type sequence I description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 6) chain A residue 20 type sequence Q description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 7) chain A residue 22 type sequence L description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 8) chain A residue 23 type sequence P description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 9) chain A residue 24 type sequence K description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 10) chain A residue 26 type sequence G description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 11) chain A residue 27 type sequence S description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 12) chain A residue 28 type sequence Y description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 13) chain A residue 30 type sequence P description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 14) chain A residue 38 type sequence F description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 15) chain A residue 39 type sequence Y description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 16) chain A residue 42 type sequence Y description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 17) chain A residue 43 type sequence K description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 18) chain A residue 65 type sequence K description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 19) chain A residue 84 type sequence Y description BINDING SITE FOR RESIDUE ST9 A 901 source : AC2 20) chain B residue 38 type sequence F description BINDING SITE FOR RESIDUE STE B 801 source : AC3 21) chain B residue 64 type sequence Y description BINDING SITE FOR RESIDUE STE B 801 source : AC3 22) chain B residue 16 type sequence V description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 23) chain B residue 19 type sequence I description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 24) chain B residue 20 type sequence Q description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 25) chain B residue 22 type sequence L description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 26) chain B residue 23 type sequence P description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 27) chain B residue 27 type sequence S description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 28) chain B residue 28 type sequence Y description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 29) chain B residue 30 type sequence P description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 30) chain B residue 38 type sequence F description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 31) chain B residue 39 type sequence Y description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 32) chain B residue 42 type sequence Y description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 33) chain B residue 43 type sequence K description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 34) chain B residue 65 type sequence K description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 35) chain B residue 84 type sequence Y description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 36) chain B residue 91 type sequence V description BINDING SITE FOR RESIDUE ST9 B 901 source : AC4 37) chain C residue 22 type sequence L description BINDING SITE FOR RESIDUE STE C 801 source : AC5 38) chain C residue 35 type sequence M description BINDING SITE FOR RESIDUE STE C 801 source : AC5 39) chain C residue 38 type sequence F description BINDING SITE FOR RESIDUE STE C 801 source : AC5 40) chain C residue 64 type sequence Y description BINDING SITE FOR RESIDUE STE C 801 source : AC5 41) chain C residue 16 type sequence V description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 42) chain C residue 19 type sequence I description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 43) chain C residue 20 type sequence Q description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 44) chain C residue 23 type sequence P description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 45) chain C residue 24 type sequence K description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 46) chain C residue 25 type sequence N description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 47) chain C residue 26 type sequence G description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 48) chain C residue 27 type sequence S description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 49) chain C residue 28 type sequence Y description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 50) chain C residue 30 type sequence P description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 51) chain C residue 38 type sequence F description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 52) chain C residue 39 type sequence Y description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 53) chain C residue 42 type sequence Y description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 54) chain C residue 43 type sequence K description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 55) chain C residue 65 type sequence K description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 56) chain C residue 84 type sequence Y description BINDING SITE FOR RESIDUE ST9 C 901 source : AC6 57) chain D residue 19 type sequence I description BINDING SITE FOR RESIDUE STE D 801 source : AC7 58) chain D residue 22 type sequence L description BINDING SITE FOR RESIDUE STE D 801 source : AC7 59) chain D residue 38 type sequence F description BINDING SITE FOR RESIDUE STE D 801 source : AC7 60) chain D residue 91 type sequence V description BINDING SITE FOR RESIDUE STE D 801 source : AC7 61) chain D residue 16 type sequence V description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 62) chain D residue 19 type sequence I description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 63) chain D residue 20 type sequence Q description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 64) chain D residue 22 type sequence L description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 65) chain D residue 23 type sequence P description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 66) chain D residue 24 type sequence K description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 67) chain D residue 26 type sequence G description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 68) chain D residue 27 type sequence S description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 69) chain D residue 28 type sequence Y description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 70) chain D residue 38 type sequence F description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 71) chain D residue 39 type sequence Y description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 72) chain D residue 42 type sequence Y description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 73) chain D residue 43 type sequence K description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 74) chain D residue 65 type sequence K description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 75) chain D residue 84 type sequence Y description BINDING SITE FOR RESIDUE ST9 D 901 source : AC8 76) chain E residue 38 type sequence F description BINDING SITE FOR RESIDUE STE E 801 source : AC9 77) chain E residue 64 type sequence Y description BINDING SITE FOR RESIDUE STE E 801 source : AC9 78) chain E residue 65 type sequence K description BINDING SITE FOR RESIDUE STE E 801 source : AC9 79) chain E residue 16 type sequence V description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 80) chain E residue 19 type sequence I description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 81) chain E residue 20 type sequence Q description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 82) chain E residue 23 type sequence P description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 83) chain E residue 27 type sequence S description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 84) chain E residue 28 type sequence Y description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 85) chain E residue 30 type sequence P description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 86) chain E residue 38 type sequence F description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 87) chain E residue 39 type sequence Y description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 88) chain E residue 42 type sequence Y description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 89) chain E residue 43 type sequence K description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 90) chain E residue 65 type sequence K description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 91) chain E residue 84 type sequence Y description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 92) chain E residue 88 type sequence M description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 93) chain E residue 91 type sequence V description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 94) chain E residue 96 type sequence I description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 95) chain F residue 11 type sequence Q description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 96) chain F residue 15 type sequence A description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 97) chain F residue 85 type sequence I description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 98) chain F residue 88 type sequence M description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 99) chain F residue 89 type sequence K description BINDING SITE FOR RESIDUE ST9 E 901 source : BC1 100) chain F residue 30 type sequence P description BINDING SITE FOR RESIDUE STE F 801 source : BC2 101) chain F residue 32 type sequence Y description BINDING SITE FOR RESIDUE STE F 801 source : BC2 102) chain F residue 35 type sequence M description BINDING SITE FOR RESIDUE STE F 801 source : BC2 103) chain F residue 36 type sequence L description BINDING SITE FOR RESIDUE STE F 801 source : BC2 104) chain F residue 38 type sequence F description BINDING SITE FOR RESIDUE STE F 801 source : BC2 105) chain F residue 65 type sequence K description BINDING SITE FOR RESIDUE STE F 801 source : BC2 106) chain E residue 88 type sequence M description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 107) chain E residue 89 type sequence K description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 108) chain E residue 92 type sequence A description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 109) chain F residue 16 type sequence V description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 110) chain F residue 19 type sequence I description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 111) chain F residue 20 type sequence Q description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 112) chain F residue 23 type sequence P description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 113) chain F residue 24 type sequence K description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 114) chain F residue 26 type sequence G description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 115) chain F residue 27 type sequence S description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 116) chain F residue 28 type sequence Y description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 117) chain F residue 38 type sequence F description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 118) chain F residue 39 type sequence Y description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 119) chain F residue 42 type sequence Y description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 120) chain F residue 43 type sequence K description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 121) chain F residue 65 type sequence K description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 122) chain F residue 84 type sequence Y description BINDING SITE FOR RESIDUE ST9 F 901 source : BC3 123) chain B residue 74 type sequence K description BINDING SITE FOR RESIDUE COA D 1099 source : BC4 124) chain D residue 54 type sequence R description BINDING SITE FOR RESIDUE COA D 1099 source : BC4 125) chain F residue 54 type sequence R description BINDING SITE FOR RESIDUE COA D 1099 source : BC4 126) chain F residue 63 type sequence R description BINDING SITE FOR RESIDUE COA D 1099 source : BC4 127) chain F residue 64 type sequence Y description BINDING SITE FOR RESIDUE COA D 1099 source : BC4 128) chain A residue 54 type sequence R description BINDING SITE FOR RESIDUE COA E 1099 source : BC5 129) chain A residue 63 type sequence R description BINDING SITE FOR RESIDUE COA E 1099 source : BC5 130) chain A residue 64 type sequence Y description BINDING SITE FOR RESIDUE COA E 1099 source : BC5 131) chain B residue 63 type sequence R description BINDING SITE FOR RESIDUE COA E 1099 source : BC5 132) chain B residue 64 type sequence Y description BINDING SITE FOR RESIDUE COA E 1099 source : BC5 133) chain C residue 74 type sequence K description BINDING SITE FOR RESIDUE COA E 1099 source : BC5 134) chain E residue 54 type sequence R description BINDING SITE FOR RESIDUE COA E 1099 source : BC5 135) chain E residue 63 type sequence R description BINDING SITE FOR RESIDUE COA E 1099 source : BC5 136) chain A residue 30-48 type prosite sequence PSYEEMLRFYSYYKQATMG description ACB_1 Acyl-CoA-binding (ACB) domain signature. PSyEeMlrFYSyYKQATmG source prosite : PS00880 137) chain A residue 19 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1 138) chain C residue 39 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 139) chain C residue 65 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 140) chain C residue 84 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 141) chain D residue 19 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1 142) chain D residue 39 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 143) chain D residue 65 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 144) chain D residue 84 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 145) chain E residue 19 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1 146) chain E residue 39 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 147) chain E residue 65 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 148) chain A residue 39 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 149) chain E residue 84 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 150) chain F residue 19 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1 151) chain F residue 39 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 152) chain F residue 65 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 153) chain F residue 84 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 154) chain A residue 65 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 155) chain A residue 84 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 156) chain B residue 19 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1 157) chain B residue 39 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 158) chain B residue 65 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 159) chain B residue 84 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 160) chain C residue 19 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1

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