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eF-site ID
|
2wed-A |
PDB Code
|
2wed |
Chain
|
A |
|
click to enlarge
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Title
|
ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE MACROCYCLIC INHIBITOR:METHYL[CYCLO-7[(2R)-((N-VALYL)AMINO)-2-(HYDROXYL-(1S)-1-METHYOXYCARBONYL-2-PHENYLETHOXY)PHOSPHINYLOXY-ETHYL]-1-NAPHTHALENEACETAMIDE], SODIUM SALT |
Classification
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HYDROLASE |
Compound
|
PENICILLOPEPSIN |
Source
|
ORGANISM_SCIENTIFIC: Penicillium janthinellum; |
|
Sequence
|
A: |
AASGVATNTPTANDEEYITPVTIGGTTLNLNFDTGSADLW
VFSTELPASQQSGHSVYNPSATGKELSGYTWSISYGDGSS
ASGNVFTDSVTVGGVTAHGQAVQAAQQISAQFQQDTNNDG
LLGLAFSSINTVQPQSQTTFFDTVKSSLAQPLFAVALKHQ
QPGVYDFGFIDSSKYTGSLTYTGVDNSQGFWSFNVDSYTA
GSQSGDGFSGIADTGTTLLLLDDSVVSQYYSQVSGAQQDS
NAGGYVFDCSTNLPDFSVSISGYTATVPGSLINYGPSGDG
STCLGGIQSNSGIGFSIFGDIFLKSQYVVFDSDGPQLGFA
PQA
|
|
Description
|
(1) |
PENICILLOPEPSIN, METHYL[CYCLO-7[(2R)-((N-VALYL)AMINO)-2-(HYDROXYL-(1S)-1-METHYLOXYCARBONYL-2-PHENYLETHOXY)PHOSPHINYLOXY-ETHYL]-1-NAPHTHALENEACETAMIDE]
|
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Functional site
|
|
1)
|
chain |
A |
residue |
33 |
type |
|
sequence |
D
|
description |
CATALYTIC SITE.
|
source |
: CIC
|
|
2)
|
chain |
A |
residue |
213 |
type |
|
sequence |
D
|
description |
CATALYTIC SITE.
|
source |
: CIC
|
|
3)
|
chain |
A |
residue |
30-41 |
type |
prosite |
sequence |
LNFDTGSADLWV
|
description |
ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LNFDTGSADLWV
|
source |
prosite : PS00141
|
|
4)
|
chain |
A |
residue |
210-221 |
type |
prosite |
sequence |
GIADTGTTLLLL
|
description |
ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LNFDTGSADLWV
|
source |
prosite : PS00141
|
|
5)
|
chain |
A |
residue |
33 |
type |
ACT_SITE |
sequence |
D
|
description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103, ECO:0000269|PubMed:5475460
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
6)
|
chain |
A |
residue |
213 |
type |
ACT_SITE |
sequence |
D
|
description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103, ECO:0000269|PubMed:5475460
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
7)
|
chain |
A |
residue |
3 |
type |
CARBOHYD |
sequence |
S
|
description |
O-linked (Man...) serine => ECO:0000269|PubMed:9836576, ECO:0000269|DOI:10.1021/ja973714r
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
8)
|
chain |
A |
residue |
7 |
type |
CARBOHYD |
sequence |
T
|
description |
O-linked (Man...) threonine => ECO:0000269|PubMed:9836576, ECO:0000269|DOI:10.1021/ja973714r
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
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