eF-site ID 2wed-A
PDB Code 2wed
Chain A

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Title ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE MACROCYCLIC INHIBITOR:METHYL[CYCLO-7[(2R)-((N-VALYL)AMINO)-2-(HYDROXYL-(1S)-1-METHYOXYCARBONYL-2-PHENYLETHOXY)PHOSPHINYLOXY-ETHYL]-1-NAPHTHALENEACETAMIDE], SODIUM SALT
Classification HYDROLASE
Compound PENICILLOPEPSIN
Source ORGANISM_SCIENTIFIC: Penicillium janthinellum;
Sequence A:  AASGVATNTPTANDEEYITPVTIGGTTLNLNFDTGSADLW
VFSTELPASQQSGHSVYNPSATGKELSGYTWSISYGDGSS
ASGNVFTDSVTVGGVTAHGQAVQAAQQISAQFQQDTNNDG
LLGLAFSSINTVQPQSQTTFFDTVKSSLAQPLFAVALKHQ
QPGVYDFGFIDSSKYTGSLTYTGVDNSQGFWSFNVDSYTA
GSQSGDGFSGIADTGTTLLLLDDSVVSQYYSQVSGAQQDS
NAGGYVFDCSTNLPDFSVSISGYTATVPGSLINYGPSGDG
STCLGGIQSNSGIGFSIFGDIFLKSQYVVFDSDGPQLGFA
PQA
Description (1)  PENICILLOPEPSIN, METHYL[CYCLO-7[(2R)-((N-VALYL)AMINO)-2-(HYDROXYL-(1S)-1-METHYLOXYCARBONYL-2-PHENYLETHOXY)PHOSPHINYLOXY-ETHYL]-1-NAPHTHALENEACETAMIDE]


Functional site

1) chain A
residue 33
type
sequence D
description CATALYTIC SITE.
source : CIC

2) chain A
residue 213
type
sequence D
description CATALYTIC SITE.
source : CIC

3) chain A
residue 30-41
type prosite
sequence LNFDTGSADLWV
description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LNFDTGSADLWV
source prosite : PS00141

4) chain A
residue 210-221
type prosite
sequence GIADTGTTLLLL
description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LNFDTGSADLWV
source prosite : PS00141

5) chain A
residue 33
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103, ECO:0000269|PubMed:5475460
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 213
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103, ECO:0000269|PubMed:5475460
source Swiss-Prot : SWS_FT_FI1

7) chain A
residue 3
type CARBOHYD
sequence S
description O-linked (Man...) serine => ECO:0000269|PubMed:9836576, ECO:0000269|DOI:10.1021/ja973714r
source Swiss-Prot : SWS_FT_FI2

8) chain A
residue 7
type CARBOHYD
sequence T
description O-linked (Man...) threonine => ECO:0000269|PubMed:9836576, ECO:0000269|DOI:10.1021/ja973714r
source Swiss-Prot : SWS_FT_FI3


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