eF-site ID 2wdt-D
PDB Code 2wdt
Chain D

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Title Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME
Classification HYDROLASE/PROTEIN BINDING
Compound UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3
Source (2WDT)
Sequence D:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ
QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGX
Description


Functional site

1) chain D
residue 42
type
sequence R
description BINDING SITE FOR RESIDUE CL D 1076
source : AC1

2) chain D
residue 33
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577
source Swiss-Prot : SWS_FT_FI10

3) chain D
residue 54
type ACT_SITE
sequence R
description Nucleophile => ECO:0000269|PubMed:20042598
source Swiss-Prot : SWS_FT_FI1

4) chain D
residue 72
type ACT_SITE
sequence R
description Nucleophile => ECO:0000269|PubMed:20042598
source Swiss-Prot : SWS_FT_FI1

5) chain D
residue 29
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127
source Swiss-Prot : SWS_FT_FI9

6) chain D
residue 6
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603
source Swiss-Prot : SWS_FT_FI5

7) chain D
residue 63
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106
source Swiss-Prot : SWS_FT_FI6

8) chain D
residue 11
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144
source Swiss-Prot : SWS_FT_FI7

9) chain D
residue 48
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144
source Swiss-Prot : SWS_FT_FI7

10) chain D
residue 27
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860
source Swiss-Prot : SWS_FT_FI8


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