eF-site/Summary 2wdt-B

eF-site ID	2wdt-B
PDB Code	2wdt
Chain	B

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Title	Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME
Classification	HYDROLASE/PROTEIN BINDING
Compound	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3
Source	(2WDT)

Sequence	B:	MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGX

Description

Functional site


1)	chain	B
	residue	42
	type
	sequence	R
	description	BINDING SITE FOR RESIDUE CL B 1076
	source	: AC2

2)	chain	B
	residue	27-52
	type	prosite
	sequence	KAKIQDKEGIPPDQQRLIFAGKQLED
	description	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD
	source	prosite : PS00299

3)	chain	B
	residue	33
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:25752577
	source	Swiss-Prot : SWS_FT_FI10

4)	chain	B
	residue	6
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16443603
	source	Swiss-Prot : SWS_FT_FI5

5)	chain	B
	residue	63
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:18719106
	source	Swiss-Prot : SWS_FT_FI6

6)	chain	B
	residue	11
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16443603, ECO:0000269\|PubMed:16543144
	source	Swiss-Prot : SWS_FT_FI7

7)	chain	B
	residue	48
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16443603, ECO:0000269\|PubMed:16543144
	source	Swiss-Prot : SWS_FT_FI7

8)	chain	B
	residue	27
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305\|PubMed:15466860
	source	Swiss-Prot : SWS_FT_FI8

9)	chain	B
	residue	29
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:25752573, ECO:0000269\|PubMed:25752577, ECO:0000269\|PubMed:34239127
	source	Swiss-Prot : SWS_FT_FI9