eF-site ID 2wdt-ABCD PDB Code 2wdt Chain A, B, C, D click to enlarge Title Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME Classification HYDROLASE/PROTEIN BINDING Compound UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3 Source (2WDT) Sequence A:  DIWTPLESNPDSLYLYSCKLGQSKLKFVDIYGFNNDLLDM IPQPVQAVIFLYPVNFDNVWFIKQYIPNSCGTIALLHLYG NLRNKFELDKDSVLDDFFNKVNEMSAEKRGQELKNNKSIE NLHHEFCGQVENRDDILDVDTHFIVFVQIEGKIIELDGRK DHPTVHCFTNGDNFLYDTGKIIQDKFIEKCKDDLRFSALA VIPN B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGX C:  NDIWTPLESNPDSLYLYSCKLGQSKLKFVDIYGFNNDLLD MIPQPVQAVIFLYPVNFDNVWFIKQYIPNSCGTIALLHLY GNLRNKFELDKDSVLDDFFNKVNEMSAEKRGQELKNNKSI ENLHHEFCGQVENRDDILDVDTHFIVFVQIEGKIIELDGR KDHPTVHCFTNGDNFLYDTGKIIQDKFIEKCKDDLRFSAL AVIPND D:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGX Description Functional site 1) chain D residue 42 type sequence R description BINDING SITE FOR RESIDUE CL D 1076 source : AC1 2) chain B residue 42 type sequence R description BINDING SITE FOR RESIDUE CL B 1076 source : AC2 3) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 4) chain A residue 92 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:20042598 source Swiss-Prot : SWS_FT_FI1 5) chain C residue 92 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:20042598 source Swiss-Prot : SWS_FT_FI1 6) chain D residue 54 type ACT_SITE sequence R description Nucleophile => ECO:0000269|PubMed:20042598 source Swiss-Prot : SWS_FT_FI1 7) chain D residue 72 type ACT_SITE sequence R description Nucleophile => ECO:0000269|PubMed:20042598 source Swiss-Prot : SWS_FT_FI1 8) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI10 9) chain D residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI10 10) chain A residue 164 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:P09936 source Swiss-Prot : SWS_FT_FI2 11) chain C residue 164 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:P09936 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 33 type SITE sequence D description Interaction with ubiquitin => ECO:0000269|PubMed:20042598 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 157 type SITE sequence D description Interaction with ubiquitin => ECO:0000269|PubMed:20042598 source Swiss-Prot : SWS_FT_FI3 14) chain A residue 219 type SITE sequence S description Interaction with ubiquitin => ECO:0000269|PubMed:20042598 source Swiss-Prot : SWS_FT_FI3 15) chain C residue 33 type SITE sequence D description Interaction with ubiquitin => ECO:0000269|PubMed:20042598 source Swiss-Prot : SWS_FT_FI3 16) chain C residue 157 type SITE sequence D description Interaction with ubiquitin => ECO:0000269|PubMed:20042598 source Swiss-Prot : SWS_FT_FI3 17) chain C residue 219 type SITE sequence S description Interaction with ubiquitin => ECO:0000269|PubMed:20042598 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 179 type SITE sequence D description Important for enzyme activity => ECO:0000250|UniProtKB:P09936 source Swiss-Prot : SWS_FT_FI4 19) chain C residue 179 type SITE sequence D description Important for enzyme activity => ECO:0000250|UniProtKB:P09936 source Swiss-Prot : SWS_FT_FI4 20) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI5 21) chain D residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI5 22) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI6 23) chain D residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI6 24) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI7 25) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI7 26) chain D residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI7 27) chain D residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI7 28) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI8 29) chain D residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI8 30) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI9 31) chain D residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI9

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