eF-site ID 2wdt-A
PDB Code 2wdt
Chain A

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Title Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME
Classification HYDROLASE/PROTEIN BINDING
Compound UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3
Source (2WDT)
Sequence A:  DIWTPLESNPDSLYLYSCKLGQSKLKFVDIYGFNNDLLDM
IPQPVQAVIFLYPVNFDNVWFIKQYIPNSCGTIALLHLYG
NLRNKFELDKDSVLDDFFNKVNEMSAEKRGQELKNNKSIE
NLHHEFCGQVENRDDILDVDTHFIVFVQIEGKIIELDGRK
DHPTVHCFTNGDNFLYDTGKIIQDKFIEKCKDDLRFSALA
VIPN
Description


Functional site

1) chain A
residue 92
type ACT_SITE
sequence C
description Nucleophile => ECO:0000269|PubMed:20042598
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 164
type ACT_SITE
sequence H
description Proton donor => ECO:0000250|UniProtKB:P09936
source Swiss-Prot : SWS_FT_FI2

3) chain A
residue 33
type SITE
sequence D
description Interaction with ubiquitin => ECO:0000269|PubMed:20042598
source Swiss-Prot : SWS_FT_FI3

4) chain A
residue 157
type SITE
sequence D
description Interaction with ubiquitin => ECO:0000269|PubMed:20042598
source Swiss-Prot : SWS_FT_FI3

5) chain A
residue 219
type SITE
sequence S
description Interaction with ubiquitin => ECO:0000269|PubMed:20042598
source Swiss-Prot : SWS_FT_FI3

6) chain A
residue 179
type SITE
sequence D
description Important for enzyme activity => ECO:0000250|UniProtKB:P09936
source Swiss-Prot : SWS_FT_FI4


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